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Abstract：
Catechins, a class of phytochemicals found in various fruits and tea leaves, have garnered attention for their diverse health-promoting properties, including their potential in combating neurodegenerative diseases. Among these catechins, (-)-epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, has emerged as a promising therapeutic agent due to its potent antioxidant and anti-inflammatory effects. Chronic neuroinflammation and oxidative stress are key pathological mechanisms in neurodegenerative diseases such as Alzheimer\'s disease (AD) and Parkinson\'s disease (PD). EGCG has neuroprotective efficacy due to scavenging free radicals, reducing oxidative stress and attenuating neuroinflammatory processes. This review discusses the molecular mechanisms of EGCG\'s anti-oxidative stress and chronic neuroinflammation, emphasizing its effects on autoimmune responses, neuroimmune system interactions, and focusing on the related effects on AD and PD. By elucidating EGCG\'s mechanisms of action and its impact on neurodegenerative processes, this review underscores the potential of EGCG as a therapeutic intervention for AD, PD, and possibly other neurodegenerative diseases. Overall, EGCG emerges as a promising natural compound for combating chronic neuroinflammation and oxidative stress, offering novel avenues for neuroprotective strategies in the treatment of neurodegenerative disorders.
摘要：
儿茶素,在各种水果和茶叶中发现的一类植物化学物质，因其多样化的健康促进特性而受到关注，包括它们对抗神经退行性疾病的潜力。在这些儿茶素中，（-）-表没食子儿茶素-3-没食子酸酯（EGCG），绿茶中最丰富的多酚，由于其有效的抗氧化和抗炎作用，已成为有前途的治疗剂。慢性神经炎症和氧化应激是阿尔茨海默病(AD)和帕金森病(PD)等神经退行性疾病的关键病理机制。EGCG具有清除自由基的神经保护作用，减少氧化应激和减弱神经炎症过程。本文综述了EGCG抗氧化应激和慢性神经炎症的分子机制,强调它对自身免疫反应的影响，神经免疫系统相互作用，并重点关注对AD和PD的相关影响。通过阐明EGCG的作用机制及其对神经退行性过程的影响，这篇综述强调了EGCG作为AD治疗干预的潜力，PD,可能还有其他神经退行性疾病。总的来说,EGCG是一种有前途的天然化合物，用于对抗慢性神经炎症和氧化应激。为神经退行性疾病的治疗提供了新的神经保护策略。
