PDF(Pubmed)
Abstract：
The National Psoriasis Foundation surveyed a random, stratified sample of individuals with psoriatic disease in the United States to determine the prevalence of an unacceptable psoriatic arthritis (PsA) symptom state and its effect on depression and social participation. Acceptable and unacceptable levels of PsA were defined using established cutoff points (acceptable ≤4 vs unacceptable >4) on the Psoriatic Arthritis Impact of Disease 9. Psoriasis severity was defined by body surface area: mild < 3%, moderate-severe ≥ 3%. Depression was assessed utilizing the Patient Health Questionnaire 2. Social participation was assessed by the Patient Reported Outcome Information Measurement System Ability to Participate in Social Role and Activities-SF4a. The analysis cohort comprised 801 patients with PsA. Unacceptable disease activity level (Psoriatic Arthritis Impact of Disease >4) was reported by 59.6% of participants. After adjusting for age, sex, and psoriasis severity, individuals with likely depression (OR = 0.014, P < .001) and those with limited ability to participate in social roles and activities (OR = 0.05, P < .001) were less likely to experience acceptable levels of PsA activity. Ultimately, the results demonstrated that most United States patients with PsA have unacceptable levels of disease activity, which is associated with increased prevalence of depression and limitations in social participation.
摘要：
国家牛皮癣基金会随机调查,美国银屑病患者的分层样本，以确定不可接受的银屑病关节炎（PsA）症状状态的患病率及其对抑郁和社会参与的影响。可接受和不可接受的PsA水平使用关于疾病9的Psoriatic关节炎影响的确定的截止点(可接受≤4vs不可接受>4)来定义。银屑病严重程度由体表面积定义：轻度<3%，中度-重度≥3%。使用患者健康问卷2评估抑郁症。通过患者报告的结果信息测量系统评估社会参与社会角色和活动的能力-SF4a。分析队列包括801例PsA患者。59.6％的参与者报告了不可接受的疾病活动水平（Psoriatic关节炎对疾病的影响>4）。在调整了年龄之后,性别,和牛皮癣的严重程度，有可能抑郁的个体(OR=0.014,P<.001)和参与社会角色和活动能力有限的个体(OR=0.05,P<.001)不太可能经历可接受的PsA活动水平。最终,结果表明，大多数美国PsA患者的疾病活动水平不可接受，这与抑郁症的患病率增加和社会参与的局限性有关。
