PDF(Pubmed)
Abstract：
UNASSIGNED: Posterior urethral valves (PUV) are the most common obstructive anomaly of the lower urinary tract in children. End-stage renal disease (ESRD) in 17% of the children is due to PUV. The present study helps know the spectrum of the disease, management options, and the outcome in these children.
UNASSIGNED: The present study is a descriptive type of study by review of medical records of all the children presented to the hospital from 2015 to 2019. Profile of PUV includes any abnormality in antenatal ultrasonography (USG), age at presentation, presenting complaints, general condition at the time of presentation, biochemical investigations like serum creatinine and electrolytes at admission, clinical progression during hospital stay and the type of intervention. Outcome variables studied were improvement in the stream and overall well-being of the child, renal function, recurrent urinary tract infections (UTIs). Follow-up period varied from 1 to 6 years.
UNASSIGNED: A total of 73 patients were included in the study. The mean age of presentation was 3.4 years. The most common presenting complaints were poor urinary stream and dribbling of urine. Antenatal USG showed abnormality in 23 patients. Renal function was abnormal in 28 patients. Out of 73 patients, 51 underwent endoscopic ablation of valves, 19 underwent vesicostomy, and three patients underwent supravesical diversion. During the follow-up recurrent UTI was observed in 11 patients, 15 patients progressed to chronic kidney disease, and 15% of patients were hypertensive. Mortality in the present study was 4%.
UNASSIGNED: PUV includes a spectrum of diseases from mild form to lethal conditions. Early intervention by relieving obstruction may prevent or delay the ESRD; hence, timely intervention is necessary in these children.
UNASSIGNED: The present study is a descriptive type of study by review of medical records of all the children presented to the hospital from 2015 to 2019. Profile of PUV includes any abnormality in antenatal ultrasonography (USG), age at presentation, presenting complaints, general condition at the time of presentation, biochemical investigations like serum creatinine and electrolytes at admission, clinical progression during hospital stay and the type of intervention. Outcome variables studied were improvement in the stream and overall well-being of the child, renal function, recurrent urinary tract infections (UTIs). Follow-up period varied from 1 to 6 years.
UNASSIGNED: A total of 73 patients were included in the study. The mean age of presentation was 3.4 years. The most common presenting complaints were poor urinary stream and dribbling of urine. Antenatal USG showed abnormality in 23 patients. Renal function was abnormal in 28 patients. Out of 73 patients, 51 underwent endoscopic ablation of valves, 19 underwent vesicostomy, and three patients underwent supravesical diversion. During the follow-up recurrent UTI was observed in 11 patients, 15 patients progressed to chronic kidney disease, and 15% of patients were hypertensive. Mortality in the present study was 4%.
UNASSIGNED: PUV includes a spectrum of diseases from mild form to lethal conditions. Early intervention by relieving obstruction may prevent or delay the ESRD; hence, timely intervention is necessary in these children.
摘要：
■后尿道瓣膜（PUV）是儿童下尿路最常见的阻塞性异常。17％的儿童的终末期肾病（ESRD）是由PUV引起的。本研究有助于了解疾病谱，管理选项，以及这些孩子的结果。
■本研究是一种描述性研究，通过审查2015年至2019年提交给医院的所有儿童的病历。PUV的轮廓包括产前超声检查（USG）中的任何异常，介绍时的年龄，提出投诉，介绍时的一般情况，入院时的生化检查，如血清肌酐和电解质，住院期间的临床进展和干预类型。研究的结果变量是儿童的流和总体幸福感的改善，肾功能,复发性尿路感染（UTI）。随访期从1年到6年不等。
■总共73名患者被纳入研究。呈现的平均年龄为3.4岁。最常见的抱怨是尿流不畅和尿液流淌。23例产前USG异常。28例患者肾功能异常。在73名患者中，51例接受内镜下瓣膜消融，19人接受了膀胱造口术，三名患者接受了膀胱上改道。随访期间，11例患者出现尿路感染复发，15名患者进展为慢性肾脏病，15%的患者为高血压。本研究中的死亡率为4%。
■PUV包括从轻度形式到致死状态的一系列疾病。通过缓解阻塞的早期干预可以预防或延迟ESRD；因此，对这些孩子进行及时的干预是必要的。
■本研究是一种描述性研究，通过审查2015年至2019年提交给医院的所有儿童的病历。PUV的轮廓包括产前超声检查（USG）中的任何异常，介绍时的年龄，提出投诉，介绍时的一般情况，入院时的生化检查，如血清肌酐和电解质，住院期间的临床进展和干预类型。研究的结果变量是儿童的流和总体幸福感的改善，肾功能,复发性尿路感染（UTI）。随访期从1年到6年不等。
■总共73名患者被纳入研究。呈现的平均年龄为3.4岁。最常见的抱怨是尿流不畅和尿液流淌。23例产前USG异常。28例患者肾功能异常。在73名患者中，51例接受内镜下瓣膜消融，19人接受了膀胱造口术，三名患者接受了膀胱上改道。随访期间，11例患者出现尿路感染复发，15名患者进展为慢性肾脏病，15%的患者为高血压。本研究中的死亡率为4%。
■PUV包括从轻度形式到致死状态的一系列疾病。通过缓解阻塞的早期干预可以预防或延迟ESRD；因此，对这些孩子进行及时的干预是必要的。
