PDF(Pubmed)
Abstract：
UNASSIGNED: Infertility is a worldwide concern, and recent research indicates that vitamin B6 deficiency may play a role in male infertility, primarily by inducing hyperhomocysteinemia and oxidative stress. These processes can have a detrimental effect on semen quality, ultimately affecting male fertility. Here, we aim to evaluate the biochemical status of pyridoxine (vitamin B6) in relation to total glutathione and total antioxidant capacity.
UNASSIGNED: A case control study samples were collected of asthenozoospermic (n = 63) and normospermic (n = 43) cases, with average men age 30.35 ± 7.03 years old. Semen plasma specimens representing both fertile and sub-fertile men visiting two different secondary care health institute in Irbid province, Jordan. All samples were assessed according to WHO guidelines (2021) and by using spectrophotometry to evaluate the semen plasma levels of vitamin B6, glutathione (GSH) and total antioxidant capacity (TAC).
UNASSIGNED: Our main finding is there is significant positive correlations between the seminal plasma concentration of GSH (p < 0.0001) and TAC (p < 0.0073) are significantly correlated with vitamin B6 deficiency in asthenozoospermia group in comparison to normozoospermia cases. A significant decrease (p < 0.0001) the levels of vitamin B6 in men with asthenozoospermia compared to normozoospermic men (control) with an approximate 80 % percent reduction in the mean levels between groups.
UNASSIGNED: These findings suggest that pyridoxine deficiency may very well alter the GSH system, in so doing affecting the antioxidant defense mechanism against reactive oxygen species to sperm, impacting sperm development and maturation. leading to asthenozoospermia.
UNASSIGNED: A case control study samples were collected of asthenozoospermic (n = 63) and normospermic (n = 43) cases, with average men age 30.35 ± 7.03 years old. Semen plasma specimens representing both fertile and sub-fertile men visiting two different secondary care health institute in Irbid province, Jordan. All samples were assessed according to WHO guidelines (2021) and by using spectrophotometry to evaluate the semen plasma levels of vitamin B6, glutathione (GSH) and total antioxidant capacity (TAC).
UNASSIGNED: Our main finding is there is significant positive correlations between the seminal plasma concentration of GSH (p < 0.0001) and TAC (p < 0.0073) are significantly correlated with vitamin B6 deficiency in asthenozoospermia group in comparison to normozoospermia cases. A significant decrease (p < 0.0001) the levels of vitamin B6 in men with asthenozoospermia compared to normozoospermic men (control) with an approximate 80 % percent reduction in the mean levels between groups.
UNASSIGNED: These findings suggest that pyridoxine deficiency may very well alter the GSH system, in so doing affecting the antioxidant defense mechanism against reactive oxygen species to sperm, impacting sperm development and maturation. leading to asthenozoospermia.
摘要：
不孕是一个世界性的问题,最近的研究表明，维生素B6缺乏可能在男性不育中起作用，主要通过诱导高同型半胱氨酸血症和氧化应激。这些过程会对精液质量产生不利影响，最终影响男性生育能力。这里,我们旨在评估吡哆醇（维生素B6）的生化状态与总谷胱甘肽和总抗氧化能力的关系。
■收集弱精子症（n=63）和正常精子症（n=43）病例的病例对照研究样本，男性平均年龄30.35±7.03岁。精液血浆标本代表了在Irbid省的两个不同的二级保健保健研究所访问的可育和低可育男性，乔丹。根据WHO指南（2021年）对所有样本进行评估，并使用分光光度法评估精液血浆中维生素B6，谷胱甘肽（GSH）和总抗氧化能力（TAC）的水平。
■我们的主要发现是精浆中GSH（p<0.0001）和TAC（p<0.0073）与弱精子症组的维生素B6缺乏之间存在显着正相关。与正常精子症男性（对照组）相比，弱精子症男性的维生素B6水平显着降低（p<0.0001），组间平均水平降低约80％。
■这些发现表明吡哆醇缺乏可能会很好地改变GSH系统，这样做会影响精子对活性氧的抗氧化防御机制，影响精子发育和成熟。导致弱精子症.
■收集弱精子症（n=63）和正常精子症（n=43）病例的病例对照研究样本，男性平均年龄30.35±7.03岁。精液血浆标本代表了在Irbid省的两个不同的二级保健保健研究所访问的可育和低可育男性，乔丹。根据WHO指南（2021年）对所有样本进行评估，并使用分光光度法评估精液血浆中维生素B6，谷胱甘肽（GSH）和总抗氧化能力（TAC）的水平。
■我们的主要发现是精浆中GSH（p<0.0001）和TAC（p<0.0073）与弱精子症组的维生素B6缺乏之间存在显着正相关。与正常精子症男性（对照组）相比，弱精子症男性的维生素B6水平显着降低（p<0.0001），组间平均水平降低约80％。
■这些发现表明吡哆醇缺乏可能会很好地改变GSH系统，这样做会影响精子对活性氧的抗氧化防御机制，影响精子发育和成熟。导致弱精子症.
