Abstract：
We assess associations of somatic and cognitive/affective depressive symptom clusters with monocyte activation (soluble (s)CD14, sCD163), systemic inflammation (interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP)), and coagulation (D-dimer, fibrinogen) in people with HIV (PWH) on suppressive antiretroviral therapy with depression. Utilizing baseline data from a randomized controlled trial, we found no significant associations in linear regression models examining individual depressive symptom clusters; however, models examining both clusters simultaneously showed that the somatic cluster was positively associated with inflammation biomarkers, while the cognitive/affective cluster was negatively associated with inflammation and coagulation biomarkers (suggesting a cooperative suppression effect). Our findings indicate a differential association with depressive symptom clusters and biological mechanisms underlying cardiovascular disease (CVD) in HIV, which may be driven by unique components of each depressive symptom cluster. This line of research could identify subgroups of PWH with depression at elevated CVD risk needing early CVD prevention approaches. Supported by R01 HL126557.
摘要：
我们评估了躯体和认知/情感抑郁症状簇与单核细胞激活（可溶性CD14，sCD163）的关联，全身性炎症（白细胞介素-6（IL-6），高敏C反应蛋白（hsCRP），和凝血（D-二聚体，纤维蛋白原）在患有抑郁症的HIV（PWH）患者中进行抑制性抗逆转录病毒治疗。利用随机对照试验的基线数据，我们在检测个体抑郁症状簇的线性回归模型中没有发现显著关联；然而，同时检查两个簇的模型表明，体细胞簇与炎症生物标志物呈正相关，而认知/情感簇与炎症和凝血生物标志物呈负相关(提示协同抑制作用).我们的研究结果表明，HIV患者的抑郁症状簇和心血管疾病（CVD）的生物学机制存在差异。这可能是由每个抑郁症状集群的独特成分驱动的。这项研究可以确定患有抑郁症的PWH亚组在CVD风险升高时需要早期CVD预防方法。由R01HL126557支持。
