Abstract：
The intricate interplay between cellular senescence and alterations in the gut microbiome emerges as a pivotal axis in the aging process, increasingly recognized for its contribution to systemic inflammation, physiological decline, and predisposition to age-associated diseases. Cellular senescence, characterized by a cessation of cell division in response to various stressors, induces morphological and functional changes within tissues. The complexity and heterogeneity of senescent cells, alongside the secretion of senescence-associated secretory phenotype, exacerbate the aging process through pro-inflammatory pathways and influence the microenvironment and immune system. Concurrently, aging-associated changes in gut microbiome diversity and composition contribute to dysbiosis, further exacerbating systemic inflammation and undermining the integrity of various bodily functions. This review encapsulates the burgeoning research on the reciprocal relationship between cellular senescence and gut dysbiosis, highlighting their collective impact on age-related musculoskeletal diseases, including osteoporosis, sarcopenia, and osteoarthritis. It also explores the potential of modulating the gut microbiome and targeting cellular senescence as innovative strategies for healthy aging and mitigating the progression of aging-related conditions. By exploring targeted interventions, including the development of senotherapeutic drugs and probiotic therapies, this review aims to shed light on novel therapeutic avenues. These strategies leverage the connection between cellular senescence and gut microbiome alterations to advance aging research and development of interventions aimed at extending health span and improving the quality of life in the older population.
摘要：
细胞衰老和肠道微生物组变化之间的复杂相互作用成为衰老过程中的关键轴，越来越多的人认识到它对全身性炎症的贡献，生理衰退，和年龄相关疾病的易感性。细胞衰老,以响应各种应激源而停止细胞分裂为特征，诱导组织内的形态和功能变化。衰老细胞的复杂性和异质性，与衰老相关的分泌表型的分泌，通过促炎途径加剧衰老过程，并影响微环境和免疫系统。同时,肠道微生物组多样性和组成的衰老相关变化导致菌群失调，进一步加剧全身炎症和破坏各种身体功能的完整性。这篇综述综述了细胞衰老与肠道菌群失调之间相互关系的新兴研究，强调它们对年龄相关的肌肉骨骼疾病的集体影响，包括骨质疏松症,少肌症,和骨关节炎。它还探讨了调节肠道微生物组和靶向细胞衰老的潜力，作为健康衰老和缓解衰老相关疾病进展的创新策略。通过探索有针对性的干预措施，包括开发治疗性药物和益生菌疗法，这篇综述旨在阐明新的治疗途径。这些策略利用细胞衰老和肠道微生物组改变之间的联系来推进衰老研究和干预措施的开发，旨在延长健康跨度和改善老年人群的生活质量。
