PDF(Pubmed)
Abstract：
Scale-free statistics of coordinated neuronal activity, suggesting a universal operating mechanism across spatio-temporal scales, have been proposed as a necessary condition of healthy resting-state brain activity. Recent studies have focused on anesthetic agents to induce distinct neural states in which consciousness is altered to understand the importance of critical dynamics. However, variation in experimental techniques, species, and anesthetics, have made comparisons across studies difficult. Here we conduct a survey of several common anesthetics (isoflurane, pentobarbital, ketamine) at multiple dosages, using calcium wide-field optical imaging of the mouse cortex. We show that while low-dose anesthesia largely preserves scale-free statistics, surgical plane anesthesia induces multiple dynamical modes, most of which do not maintain critical avalanche dynamics. Our findings indicate multiple pathways away from default critical dynamics associated with quiet wakefulness, not only reflecting differences between these common anesthetics but also showing significant variations in individual responses. This is suggestive of a non-trivial relationship between criticality and the underlying state of the subject.
摘要：
协调神经元活动的无标度统计，提出了一种跨时空尺度的通用运行机制，已被认为是健康静息状态大脑活动的必要条件。最近的研究集中在麻醉剂上，以诱导不同的神经状态，其中意识被改变以了解关键动力学的重要性。然而,实验技术的变化，物种,和麻醉剂，使跨研究的比较变得困难。在这里，我们对几种常见的麻醉药（异氟烷，戊巴比妥,氯胺酮)多剂量，利用钙对小鼠皮层进行广域光学成像。我们表明，虽然低剂量麻醉在很大程度上保留了无标度统计数据，手术平面麻醉诱导多种动力学模式，其中大多数不保持关键的雪崩动力学。我们的发现表明，远离与安静觉醒相关的默认关键动态的多种途径，不仅反映了这些常见麻醉药之间的差异，而且还显示出个体反应的显着差异。这暗示了临界性与主体的基本状态之间的非平凡关系。
