Abstract：
OBJECTIVE: Provide an overview of scientific reports and literature related to the role(s) of phytocompounds and nutrients in neuroprotection. Discuss how these properties may inform nutrition- and dietary interventions to mitigate chemotherapy-induced peripheral neuropathy (CIPN), for which there are no effective treatments.
METHODS: A literature search (2010-2023) was conducted in PubMed and Google Scholar where search terms-diet, nutrition, neuroprotection, neurodegenerative diseases, and social determinants of health-were used to narrow articles. From this search, manuscripts were reviewed to provide an overview of the neuroprotective properties of various phytocompounds and nutrients and their observed effects in neurodegenerative conditions and CIPN. Social determinant of health factors (SDOH) related to economic stability and access to nutritious foods were also reviewed as potential barriers to dietary interventions.
RESULTS: Twenty-eight publications were included in this literature review. Phytocompounds found in green tea (EGCG), turmeric (curcumin), cruciferous vegetables (sulforaphane), as well as certain vitamins, are promising, targeted interventions to mitigate CIPN. SDOH factors such as economic instability and limited access to nutritious foods may act as barriers to dietary interventions and limit their generalizability.
CONCLUSIONS: Dietary interventions focused on the use of phytocompounds and vitamins with known antioxidant, anti-inflammatory, and neuroprotective properties, hold promise and may provide patients with natural, non-pharmacological therapeutics for the management and/or prevention of CIPN. However, rigorous clinical trial research is needed to explore these effects in humans.
CONCLUSIONS: Nurses support cancer survivors at the point-of-care, particularly during and after neurotoxic chemotherapy treatments. If future research supports dietary interventions to mitigate CIPN, nurses will ultimately be positioned to help translate this knowledge into clinical practice through educating patients on how to infuse nutrient-rich foods into their diets. Further, nurses will need to be conscious of SDOH factors that may impede access to these foods.
METHODS: A literature search (2010-2023) was conducted in PubMed and Google Scholar where search terms-diet, nutrition, neuroprotection, neurodegenerative diseases, and social determinants of health-were used to narrow articles. From this search, manuscripts were reviewed to provide an overview of the neuroprotective properties of various phytocompounds and nutrients and their observed effects in neurodegenerative conditions and CIPN. Social determinant of health factors (SDOH) related to economic stability and access to nutritious foods were also reviewed as potential barriers to dietary interventions.
RESULTS: Twenty-eight publications were included in this literature review. Phytocompounds found in green tea (EGCG), turmeric (curcumin), cruciferous vegetables (sulforaphane), as well as certain vitamins, are promising, targeted interventions to mitigate CIPN. SDOH factors such as economic instability and limited access to nutritious foods may act as barriers to dietary interventions and limit their generalizability.
CONCLUSIONS: Dietary interventions focused on the use of phytocompounds and vitamins with known antioxidant, anti-inflammatory, and neuroprotective properties, hold promise and may provide patients with natural, non-pharmacological therapeutics for the management and/or prevention of CIPN. However, rigorous clinical trial research is needed to explore these effects in humans.
CONCLUSIONS: Nurses support cancer survivors at the point-of-care, particularly during and after neurotoxic chemotherapy treatments. If future research supports dietary interventions to mitigate CIPN, nurses will ultimately be positioned to help translate this knowledge into clinical practice through educating patients on how to infuse nutrient-rich foods into their diets. Further, nurses will need to be conscious of SDOH factors that may impede access to these foods.
摘要：
目的：提供与植物化合物和营养素在神经保护中的作用有关的科学报告和文献的概述。讨论这些特性如何为营养和饮食干预提供信息，以减轻化疗引起的周围神经病变（CIPN），没有有效的治疗方法。
方法：在PubMed和GoogleScholar中进行了文献检索（2010-2023年），其中搜索词-饮食，营养,神经保护,神经退行性疾病，和健康的社会决定因素-被用来缩小文章。从这次搜索中，综述了手稿，以概述各种植物化合物和营养素的神经保护特性及其在神经退行性疾病和CIPN中观察到的作用。与经济稳定和获得营养食品有关的健康因素（SDOH）的社会决定因素也被视为饮食干预的潜在障碍。
结果：本文献综述包括28篇出版物。绿茶（EGCG）中发现的植物化合物，姜黄（姜黄素），十字花科蔬菜（萝卜硫烷），以及某些维生素，很有希望，有针对性的干预措施减轻CIPN。SDOH因素，如经济不稳定和获得营养食品的机会有限，可能会成为饮食干预的障碍，并限制其普遍性。
结论：饮食干预侧重于使用植物化合物和维生素以及已知的抗氧化剂，抗炎,和神经保护特性，抱有希望，可以为患者提供自然，用于管理和/或预防CIPN的非药物疗法。然而,需要严格的临床试验研究来探索这些对人类的影响。
结论：护士在护理点为癌症幸存者提供支持，特别是在神经毒性化疗期间和之后。如果未来的研究支持饮食干预以减轻CIPN，护士最终将通过教育患者如何在饮食中注入营养丰富的食物来帮助将这些知识转化为临床实践。Further,护士需要意识到可能阻碍获得这些食物的SDOH因素。
方法：在PubMed和GoogleScholar中进行了文献检索（2010-2023年），其中搜索词-饮食，营养,神经保护,神经退行性疾病，和健康的社会决定因素-被用来缩小文章。从这次搜索中，综述了手稿，以概述各种植物化合物和营养素的神经保护特性及其在神经退行性疾病和CIPN中观察到的作用。与经济稳定和获得营养食品有关的健康因素（SDOH）的社会决定因素也被视为饮食干预的潜在障碍。
结果：本文献综述包括28篇出版物。绿茶（EGCG）中发现的植物化合物，姜黄（姜黄素），十字花科蔬菜（萝卜硫烷），以及某些维生素，很有希望，有针对性的干预措施减轻CIPN。SDOH因素，如经济不稳定和获得营养食品的机会有限，可能会成为饮食干预的障碍，并限制其普遍性。
结论：饮食干预侧重于使用植物化合物和维生素以及已知的抗氧化剂，抗炎,和神经保护特性，抱有希望，可以为患者提供自然，用于管理和/或预防CIPN的非药物疗法。然而,需要严格的临床试验研究来探索这些对人类的影响。
结论：护士在护理点为癌症幸存者提供支持，特别是在神经毒性化疗期间和之后。如果未来的研究支持饮食干预以减轻CIPN，护士最终将通过教育患者如何在饮食中注入营养丰富的食物来帮助将这些知识转化为临床实践。Further,护士需要意识到可能阻碍获得这些食物的SDOH因素。
