Abstract：
Hypoxic-ischemic encephalopathy (HIE) is a brain injury induced by many causes of cerebral tissue ischemia and hypoxia. Although HIE may occur at many ages, its impact on the neonatal brain is greater because it occurs during the formative stage. Recent research suggests that histone modifications may occur in the human brain in response to acute stress events, resulting in transcriptional changes and HIE development. Because there are no safe and effective therapies for HIE, researchers have focused on HIE treatments that target histone modifications. In this review, four main histone modifications are explored, histone methylation, acetylation, phosphorylation, and crotonylation, as well as their relevance to HIE. The efficacy of histone deacetylase inhibitors in the treatment of HIE is also explored. In conclusion, targeting histone modifications may be a novel strategy for elucidating the mechanism of HIE, as well as a novel approach to HIE treatment.
摘要：
缺氧缺血性脑病(HIE)是由多种原因引起的脑组织缺血缺氧所致的脑损伤。虽然HIE可能发生在许多年龄，它对新生儿大脑的影响更大，因为它发生在形成阶段。最近的研究表明，组蛋白修饰可能发生在人类大脑中，以应对急性应激事件，导致转录变化和HIE发育。因为HIE没有安全有效的治疗方法，研究人员专注于针对组蛋白修饰的HIE治疗。在这次审查中,探索了四个主要的组蛋白修饰，组蛋白甲基化，乙酰化,磷酸化,和巴豆酰化，以及它们与HIE的相关性。还探讨了组蛋白脱乙酰酶抑制剂在治疗HIE中的功效。总之,靶向组蛋白修饰可能是阐明HIE机制的新策略，以及HIE治疗的新方法。
