Abstract：
The synovium plays a crucial role in diarthrodial joint health, and its study has garnered appreciation as synovitis has been linked to osteoarthritis symptoms and progression. Quantitative synovium structure-function data, however, remain sparse. In the present study, we hypothesized that tissue glycosaminoglycan (GAG) content contributes to the low friction properties of the synovium. Bovine and human synovium tribological properties were evaluated using a custom friction testing device in two different cases: (1) proteoglycan depletion to isolate the influence of tissue GAGs in the synovium friction response and (2) interleukin-1 (IL) treatment to observe inflammation-induced structural and functional changes. Following proteoglycan depletion, synovium friction coefficients increased while GAG content decreased. Conversely, synovium explants treated with the proinflammatory cytokine IL exhibited elevated GAG concentrations and decreased friction coefficients. For the first time, a relationship between synovium friction coefficient and GAG concentration is demonstrated. The study of synovium tribology is necessary to fully understand the mechanical environment of the healthy and diseased joint.
摘要：
滑膜在关节滑膜的健康中起着至关重要的作用，由于滑膜炎与骨关节炎的症状和进展有关，因此其研究获得了赞赏。定量滑膜结构-功能数据，然而,保持稀疏。在本研究中,我们假设组织糖胺聚糖（GAG）含量有助于滑膜的低摩擦特性。在两种不同的情况下，使用定制的摩擦测试设备评估了牛和人滑膜的摩擦学特性：（1）蛋白聚糖消耗以分离组织GAG在滑膜摩擦反应中的影响，以及（2）白介素-1（IL）治疗以观察炎症诱导的结构和功能变化。蛋白聚糖耗尽后，滑膜摩擦系数增加而GAG含量降低。相反，用促炎细胞因子IL处理的滑膜外植体表现出升高的GAG浓度和降低的摩擦系数。第一次,证明了滑膜摩擦系数与GAG浓度之间的关系。滑膜摩擦学的研究对于充分了解健康和患病关节的机械环境是必要的。
