Abstract：
Androgenic alopecia (AGA) typically manifests post-puberty, resulting in decreases in hair density, disruptions in the hair growth cycle, and alterations in hair follicle micro structure. Dihydrotestosterone (DHT) is a key hormone implicated in hair loss, especially on male. In this study, we found that each of arginine (Arg), arterial extract (AE) or biotin tripeptide-1 (BT-1), when combined with low level light therapy (LLLT, at 630 nm, 2 J/cm2), showed the efficacy in enhancing mitochondrial functions, cell proliferation and collagen synthesis in fibroblasts. Additionally, CARRIPOWER (the complexes of AE, BT-1, Arg, and Diaminopyrimidine derivatives), in conjunction with LLLT (630 nm, 2 J/cm2), showed promising results in dermal papilla cells (DPCs). The promising results contained not also inflammatory cytokines (IL-1β and IL-6) and cell pro apoptotic factor (TGF-β2) reduction, but also Wnt pathway inhibition by decreasing DKK1 level, and pro-hair growth factors (vascular endothelial growth factor (VEGF) and β-catenin) increase. This innovative combination therapy offers a potential solution for the treatment of AGA, addressing both hormonal and cellular factors involved in hair loss.
摘要：
雄激素性脱发（AGA）通常表现为青春期后，导致头发密度降低，头发生长周期的中断，毛囊微结构的改变。双氢睾酮（DHT）是与脱发有关的关键激素，尤其是男性。在这项研究中,我们发现每个精氨酸（Arg），动脉提取物（AE）或生物素三肽-1（BT-1），当与低水平光疗法(LLLT，在630nm，2J/cm2),显示了增强线粒体功能的功效，成纤维细胞的细胞增殖和胶原合成。此外,CARRIPOWER(AE的复合物，BT-1,Arg,和二氨基嘧啶衍生物），与LLLT（630nm，2J/cm2),在真皮乳头细胞（DPC）中显示出有希望的结果。有希望的结果不包括炎性细胞因子（IL-1β和IL-6）和细胞促凋亡因子（TGF-β2）的减少，但也通过降低DKK1水平来抑制Wnt途径，和前毛发生长因子（血管内皮生长因子（VEGF）和β-catenin）增加。这种创新的联合疗法为AGA的治疗提供了潜在的解决方案，解决与脱发有关的激素和细胞因子。
