Abstract：
Cardiovascular diseases (CVDs) represent a significant public health concern because of their associations with inflammation, oxidative stress, and abnormal remodeling of the heart and blood vessels. In this review, we discuss the intricate interplay between mitochondria-associated membranes (MAMs) and cardiovascular inflammation, highlighting their role in key cellular processes such as calcium homeostasis, lipid metabolism, oxidative stress management, and ERS. We explored how these functions impact the pathogenesis and progression of various CVDs, including myocardial ischemia-reperfusion injury, atherosclerosis, diabetic cardiomyopathy, cardiovascular aging, heart failure, and pulmonary hypertension. Additionally, we examined current therapeutic strategies targeting MAM-related pathways and proteins, emphasizing the potential of MAMs as therapeutic targets. Our review aims to provide new insights into the mechanisms of cardiovascular inflammation and propose novel therapeutic approaches to improve cardiovascular health outcomes.
摘要：
心血管疾病（CVDs）是一个重要的公共卫生问题，因为它们与炎症有关。氧化应激，心脏和血管的异常重塑。在这次审查中,我们讨论了线粒体相关膜（MAMs）和心血管炎症之间的复杂相互作用，强调它们在关键细胞过程中的作用，如钙稳态，脂质代谢，氧化应激管理，和ERS。我们探索了这些功能如何影响各种CVD的发病机制和进展，包括心肌缺血再灌注损伤,动脉粥样硬化,糖尿病性心肌病,心血管老化，心力衰竭,和肺动脉高压。此外,我们研究了目前针对MAM相关途径和蛋白质的治疗策略，强调MAMs作为治疗靶点的潜力。我们的综述旨在为心血管炎症的机制提供新的见解，并提出新的治疗方法来改善心血管健康结果。
