Abstract：
UNASSIGNED: To determine the relationship between carotid artery stenosis (CAS) and the development of open-angle glaucoma (OAG) in the Taiwanese population.
UNASSIGNED: This retrospective cohort study was conducted using Chang Gung Research Database. Cox-proportional hazards model was applied to calculate the hazard ratio for OAG between CAS and the control cohort.
UNASSIGNED: Among 19,590 CAS patients, 17,238 had mild CAS (<50%), 1,895 had moderate CAS (50-69%), and 457 had severe CAS (≥70%). The CAS cohort had a higher proportion of several comorbidities. After adjusting for comorbidities, no significant difference in OAG development was found between CAS and control cohorts. Matching for key comorbidities, no significant differences in OAG incidence were found between matched cohorts (P = .869). Subdividing the matched CAS cohort by stenosis severity: mild (<50%), moderate (50-69%), and severe (≥70%), a statistically significantly lower OAG risk was observed in patients with mild CAS stenosis (HR: 1.12, 95% CI = 1.03-1.21, P = .006). Kaplan-Meier analysis revealed reduced OAG incidence in CAS patients who underwent surgical intervention, compared to the control cohort (P <.001). Subgroup analysis revealed that patients in the mild CAS stenosis group, those who underwent surgical intervention exhibited a reduced OAG risk (HR: 0.29, 95% CI = 0.15-0.58, P = .001).
UNASSIGNED: No statistically significant differences in OAG risk were observed between patients with CAS and the control cohort. The severity of CAS appears to influence OAG risk, with surgical intervention potentially offering protective effects, particularly in patients with mild CAS stenosis (<50%), suggesting that enhanced ocular perfusion post-surgery may act as a protective factor against OAG development.
UNASSIGNED: This retrospective cohort study was conducted using Chang Gung Research Database. Cox-proportional hazards model was applied to calculate the hazard ratio for OAG between CAS and the control cohort.
UNASSIGNED: Among 19,590 CAS patients, 17,238 had mild CAS (<50%), 1,895 had moderate CAS (50-69%), and 457 had severe CAS (≥70%). The CAS cohort had a higher proportion of several comorbidities. After adjusting for comorbidities, no significant difference in OAG development was found between CAS and control cohorts. Matching for key comorbidities, no significant differences in OAG incidence were found between matched cohorts (P = .869). Subdividing the matched CAS cohort by stenosis severity: mild (<50%), moderate (50-69%), and severe (≥70%), a statistically significantly lower OAG risk was observed in patients with mild CAS stenosis (HR: 1.12, 95% CI = 1.03-1.21, P = .006). Kaplan-Meier analysis revealed reduced OAG incidence in CAS patients who underwent surgical intervention, compared to the control cohort (P <.001). Subgroup analysis revealed that patients in the mild CAS stenosis group, those who underwent surgical intervention exhibited a reduced OAG risk (HR: 0.29, 95% CI = 0.15-0.58, P = .001).
UNASSIGNED: No statistically significant differences in OAG risk were observed between patients with CAS and the control cohort. The severity of CAS appears to influence OAG risk, with surgical intervention potentially offering protective effects, particularly in patients with mild CAS stenosis (<50%), suggesting that enhanced ocular perfusion post-surgery may act as a protective factor against OAG development.
摘要：
■确定台湾人群中颈动脉狭窄（CAS）与开角型青光眼（OAG）发展之间的关系。
■这项回顾性队列研究使用长贡研究数据库进行。Cox比例风险模型用于计算CAS和对照组之间OAG的风险比。
■在19,590名CAS患者中，17,238患有轻度CAS（<50%），1,895具有中度CAS（50-69％），457例患有重度CAS(≥70%)。CAS队列中几种合并症的比例较高。调整合并症后，在CAS和对照组之间,OAG发展没有显著差异.匹配关键合并症，匹配队列之间的OAG发生率无显著差异(P=.869).根据狭窄严重程度细分匹配的CAS队列：轻度（<50％），中等（50-69%），严重（≥70%），轻度CAS狭窄患者的OAG风险显著降低(HR:1.12,95%CI=1.03-1.21,P=.006).Kaplan-Meier分析显示，接受手术干预的CAS患者OAG发生率降低，与对照组相比（P<.001）。亚组分析显示，轻度CAS狭窄组患者，接受手术干预的患者OAG风险降低(HR:0.29,95%CI=0.15~0.58,P=.001).
■在CAS患者和对照组之间没有观察到OAG风险的统计学差异。CAS的严重程度似乎会影响OAG风险，手术干预可能提供保护作用，尤其是轻度CAS狭窄患者（<50%），提示术后眼灌注增强可能是防止OAG发展的保护因素。
■这项回顾性队列研究使用长贡研究数据库进行。Cox比例风险模型用于计算CAS和对照组之间OAG的风险比。
■在19,590名CAS患者中，17,238患有轻度CAS（<50%），1,895具有中度CAS（50-69％），457例患有重度CAS(≥70%)。CAS队列中几种合并症的比例较高。调整合并症后，在CAS和对照组之间,OAG发展没有显著差异.匹配关键合并症，匹配队列之间的OAG发生率无显著差异(P=.869).根据狭窄严重程度细分匹配的CAS队列：轻度（<50％），中等（50-69%），严重（≥70%），轻度CAS狭窄患者的OAG风险显著降低(HR:1.12,95%CI=1.03-1.21,P=.006).Kaplan-Meier分析显示，接受手术干预的CAS患者OAG发生率降低，与对照组相比（P<.001）。亚组分析显示，轻度CAS狭窄组患者，接受手术干预的患者OAG风险降低(HR:0.29,95%CI=0.15~0.58,P=.001).
■在CAS患者和对照组之间没有观察到OAG风险的统计学差异。CAS的严重程度似乎会影响OAG风险，手术干预可能提供保护作用，尤其是轻度CAS狭窄患者（<50%），提示术后眼灌注增强可能是防止OAG发展的保护因素。
