Abstract：
Low-intensity focused ultrasound represents groundbreaking medical advancements, characterized by its noninvasive feature, safety, precision, and broad neuromodulatory capabilities. This technology operates through mechanisms, for example, acoustic radiation force, cavitation, and thermal effects. Notably, with the evolution of medical technology, ultrasound neuromodulation has been gradually applied in treating central nervous system diseases, especially stroke. Furthermore, burgeoning research areas such as sonogenetics and nanotechnology show promising potential. Despite the benefit of low-intensity focused ultrasound the precise biophysical mechanism of ultrasound neuromodulation still need further exploration. This review discusses the recent and ongoing developments of low-intensity focused ultrasound for neurological regulation, covering the underlying rationale to current utility and the challenges that impede its further development and broader adoption of this promising alternative to noninvasive therapy.
摘要：
低强度聚焦超声代表了突破性的医学进步，以其非侵入性特征为特征，安全,精度,和广泛的神经调节能力。这项技术通过机制运作，例如,声辐射力，空化,和热效应。值得注意的是,随着医疗技术的发展，超声神经调制已逐步应用于中枢神经系统疾病的治疗,尤其是中风。此外，超声遗传学和纳米技术等新兴研究领域显示出有希望的潜力。尽管低强度聚焦超声具有优势，但超声神经调节的精确生物物理机制仍需进一步探索。这篇综述讨论了低强度聚焦超声在神经调节方面的最新发展。涵盖了当前效用的基本原理，以及阻碍其进一步发展和更广泛采用这种有希望的非侵入性疗法的挑战。
