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Abstract：
Alzheimer\'s disease (AD) is the most common neurodegenerative disease in the central nervous system, characterized by memory and cognitive dysfunction. Acupuncture is an effective means to alleviate the symptoms of AD. Recent studies have shown that microglia play an important role in the occurrence and development of AD. Acupuncture can regulate the activity of microglia, inhibit neuroinflammation, regulate phagocytosis, and clear Aβ Pathological products such as plaque can protect nerve cells and improve cognitive function in AD patients. This article summarizes the relationship between microglia and AD, as well as the research progress in the mechanism of acupuncture regulating microglia in the treatment of AD. The mechanism of acupuncture regulating microglia in the treatment of AD is mainly reviewed from two aspects: inhibiting neuroinflammatory activity and regulating phagocytic function.
摘要：
阿尔茨海默病(Alzheimer’sdisease,AD)是中枢神经系统最常见的神经退行性疾病,以记忆和认知功能障碍为特征。针刺是缓解AD症状的有效手段。近年来的研究表明,小胶质细胞在AD的发生、发展中起着重要作用。针刺可以调节小胶质细胞的活性,抑制神经炎症，调节吞噬作用，明确Aβ斑块等病理产物可以保护神经细胞,改善AD患者的认知功能。本文综述了小胶质细胞与AD的关系,以及针刺调节小胶质细胞治疗AD的机制研究进展。主要从抑制神经炎症活性和调节吞噬功能两个方面综述了针刺调节小胶质细胞治疗AD的机制。
