PDF(Pubmed)
Abstract：
UNASSIGNED: The Life\'s Simple 7 score (LS7) promotes cardiovascular health (CVH). Despite this, some with optimal LS7 develop cardiovascular disease (CVD), while others with poor CVH do not, termed the \"CVH paradox.\" This paper explores pathways explaining this paradox.
UNASSIGNED: We examined methodological aspects: 1) misclassification bias in self-reported lifestyle factors (smoking, physical activity, diet); 2) cumulative exposure to risk factors over a lifetime, impacting the CVH paradox. Punctual risk factor assessments are suboptimal for predicting outcomes. We proposed personalized prevention using \"novel\" elements to refine CVH assessment: 1) subclinical vascular disease markers, 2) metabolic biomarkers in blood and urine, 3) emerging risk factors, 4) polygenic risk scores (PRS), 5) epigenetics, and 6) the exposome.
UNASSIGNED: Addressing the CVH paradox requires a multifaceted approach, reducing misclassification bias, considering cumulative risk exposure, and incorporating novel personalized prevention elements.
UNASSIGNED: A holistic, individualized approach to CVH assessment and CVD prevention can better reduce cardiovascular outcomes and improve population health. Collaboration among researchers, healthcare providers, policymakers, and communities is essential for effective implementation and realization of these strategies.
UNASSIGNED: We examined methodological aspects: 1) misclassification bias in self-reported lifestyle factors (smoking, physical activity, diet); 2) cumulative exposure to risk factors over a lifetime, impacting the CVH paradox. Punctual risk factor assessments are suboptimal for predicting outcomes. We proposed personalized prevention using \"novel\" elements to refine CVH assessment: 1) subclinical vascular disease markers, 2) metabolic biomarkers in blood and urine, 3) emerging risk factors, 4) polygenic risk scores (PRS), 5) epigenetics, and 6) the exposome.
UNASSIGNED: Addressing the CVH paradox requires a multifaceted approach, reducing misclassification bias, considering cumulative risk exposure, and incorporating novel personalized prevention elements.
UNASSIGNED: A holistic, individualized approach to CVH assessment and CVD prevention can better reduce cardiovascular outcomes and improve population health. Collaboration among researchers, healthcare providers, policymakers, and communities is essential for effective implementation and realization of these strategies.
摘要：
■生活简单7分（LS7）促进心血管健康（CVH）。尽管如此,一些具有最佳LS7的人发展为心血管疾病(CVD)，而其他CVH较差的人则没有，被称为“CVH悖论”。“本文探讨了解释这一悖论的途径。
■我们研究了方法学方面：1)自我报告的生活方式因素(吸烟，身体活动,饮食)；2)终生累积暴露于危险因素，影响了CVH悖论。准时的风险因素评估对于预测结果是次优的。我们提出了个性化预防使用“新”元素来完善CVH评估：1)亚临床血管疾病标志物，2）血液和尿液中的代谢生物标志物，3)新兴风险因素，4)多基因风险评分(PRS)，5）表观遗传学，和6）曝光。
■解决CVH悖论需要多方面的方法，减少误分类偏差，考虑到累积风险敞口，并结合了新颖的个性化预防元素。
■整体，CVH评估和CVD预防的个体化方法可以更好地降低心血管结局并改善人群健康.研究人员之间的合作，医疗保健提供者，政策制定者，和社区对于有效实施和实现这些战略至关重要。
■我们研究了方法学方面：1)自我报告的生活方式因素(吸烟，身体活动,饮食)；2)终生累积暴露于危险因素，影响了CVH悖论。准时的风险因素评估对于预测结果是次优的。我们提出了个性化预防使用“新”元素来完善CVH评估：1)亚临床血管疾病标志物，2）血液和尿液中的代谢生物标志物，3)新兴风险因素，4)多基因风险评分(PRS)，5）表观遗传学，和6）曝光。
■解决CVH悖论需要多方面的方法，减少误分类偏差，考虑到累积风险敞口，并结合了新颖的个性化预防元素。
■整体，CVH评估和CVD预防的个体化方法可以更好地降低心血管结局并改善人群健康.研究人员之间的合作，医疗保健提供者，政策制定者，和社区对于有效实施和实现这些战略至关重要。
