PDF(Pubmed)
Abstract：
Epididymis plays a vital role in promoting sperm maturation and maintaining sperm viability. It has been shown the presence of nonviable sperm in cauda epididymis. We previously identified a secretory protein (260/280KDa oligomers) of hamster cauda epididymal principal cells that binds to nonviable sperm. The 260/280KDa oligomers are composed of 64kDa FGL2 (fibrinogen-like protein-2) and 33kDa FGL1) (fibrinogen-like protein-1). In addition, we have demonstrated that FGL2 is a phospholipid-activated serine protease; the conversion of prothrombin to thrombin by FGL2 followed by the conversion of soluble fibrinogen to insoluble fibrin polymers by thrombin. In the present study, we have shown the presence of a 56kDa fibrinogen β in hamster cauda sperm. The potential role of fibrinogen in hamster physiology is being discussed.
摘要：
附睾在促进精子成熟和维持精子活力方面起着至关重要的作用。已显示附睾中存在无法存活的精子。我们先前鉴定了仓鼠尾附睾主要细胞的分泌蛋白（260/280KDa寡聚物），该蛋白与无法存活的精子结合。260/280KDa寡聚体由64kDaFGL2(纤维蛋白原样蛋白-2)和33kDaFGL1(纤维蛋白原样蛋白-1)组成。此外,我们已经证明FGL2是磷脂激活的丝氨酸蛋白酶;通过FGL2将凝血酶原转化为凝血酶,然后通过凝血酶将可溶性纤维蛋白原转化为不溶性纤维蛋白聚合物。在本研究中,我们已经显示了仓鼠尾精子中存在56kDa的纤维蛋白原β。纤维蛋白原在仓鼠生理学中的潜在作用正在讨论中。
