PDF(Pubmed)
Abstract：
UNASSIGNED: The persistence of symptoms for ≥12 weeks after a COVID-19 infection is known as Long COVID (LC), a condition with unclear pathophysiology and no proven treatments to date. Living with obesity is a risk factor for LC and has symptoms which may overlap with and aggravate LC.
UNASSIGNED: ReDIRECT is a remotely delivered trial assessing whether weight management can reduce LC symptoms. We recruited people with LC and BMI >27kg/m 2. The intervention was delivered remotely by dietitians, with online data collection (medical and dietary history, COVID-19 infection and vaccination, body composition, LC history/symptoms, blood pressure, quality of life, sociodemographic data). Participants self-selected the dominant LC symptoms they most wanted to improve from the intervention.
UNASSIGNED: Participants (n=234) in England (64%) and Scotland (30%) were mainly women (85%) of white ethnicity (90%), with 13% living in the 20% most deprived areas, a mean age of 46 (SD10) years, and median BMI of 35kg/m 2 (IQR 32-40). Before starting the study, 30% reported more than one COVID-19 infection (82% confirmed with one or more positive tests). LC Diagnosis was mainly by GPs (71%), other healthcare professionals (9%), or self-diagnosed (21%). The median total number of symptoms was 6 (IQR 4-8). Self-selected dominant LC symptoms included fatigue (54%), breathlessness (16%), pain (12%), anxiety/depression (1%) and \"other\" (17%). At baseline, 82% were taking medication, 57% reported 1+ other medical conditions. Quality of life was poor; 20% were on long-term sick leave or reduced working hours. Most (92%) reported having gained weight since contracting COVID-19 (median weight change +11.5 kg, range -11.5 to +45.3 kg).
UNASSIGNED: Symptoms linked to LC and overweight are diverse and complex. Remote trial delivery enabled rapid recruitment across the UK yet certain groups (e.g. men and those from ethnic minority groups) were under-represented.
UNASSIGNED: ISRCTN registry ( ISRCTN12595520, 25/11/2021).
Long COVID (LC, symptoms lasting 12 weeks or more after a COVID-19 infection) is a poorly understood condition, with no proven treatments. Living with obesity increases the risk of developing LC; symptoms of obesity overlap and aggravate those of LC. The ReDIRECT study tests, in people living with both LC and overweight, whether weight management can reduce LC symptoms. The study involves total diet replacement (with porridge, soups and shakes) for 12 weeks and is delivered remotely, with dietitian support via internet and/or phone. Researchers collected all data via online forms (medical and diet history, COVID-19 infection and vaccination, weight, height, LC history and symptoms, blood pressure, quality of life, and other demographic data). Each participant selected the LC symptom they most wanted to see improve. Participants (n=234) lived across the UK, were mainly women (85%) of white ethnicity (90%), with 13% living in the 20% most deprived areas. Their average age was 46 years old with an average body mass index (BMI) of 35kg/m 2. Diagnosis of LC was mainly by GPs (71%), other healthcare professionals (9%), or self-diagnosed (21%). Participants reported on average 6 symptoms each, identifying fatigue (54%), breathlessness (16%), pain (12%), anxiety/depression (1%) and \"other\" (17%) as the symptom they would most like to see improve. At the start of the study, most (82%) were taking medication, half (57%) reported 1+ other medical conditions. Quality of life was poor, and 20% were on long-term sick leave or reduced working hours. Most (92%) reported gaining weight since contracting COVID-19, on average +11.5 kg. The baseline characteristics of ReDIRECT study participants show that symptoms linked to LC and overweight are diverse and complex. The study being “remote” means that recruitment was rapid and across the UK, yet certain groups (e.g. men and those from ethnic minority groups) were under-represented.
UNASSIGNED: ReDIRECT is a remotely delivered trial assessing whether weight management can reduce LC symptoms. We recruited people with LC and BMI >27kg/m 2. The intervention was delivered remotely by dietitians, with online data collection (medical and dietary history, COVID-19 infection and vaccination, body composition, LC history/symptoms, blood pressure, quality of life, sociodemographic data). Participants self-selected the dominant LC symptoms they most wanted to improve from the intervention.
UNASSIGNED: Participants (n=234) in England (64%) and Scotland (30%) were mainly women (85%) of white ethnicity (90%), with 13% living in the 20% most deprived areas, a mean age of 46 (SD10) years, and median BMI of 35kg/m 2 (IQR 32-40). Before starting the study, 30% reported more than one COVID-19 infection (82% confirmed with one or more positive tests). LC Diagnosis was mainly by GPs (71%), other healthcare professionals (9%), or self-diagnosed (21%). The median total number of symptoms was 6 (IQR 4-8). Self-selected dominant LC symptoms included fatigue (54%), breathlessness (16%), pain (12%), anxiety/depression (1%) and \"other\" (17%). At baseline, 82% were taking medication, 57% reported 1+ other medical conditions. Quality of life was poor; 20% were on long-term sick leave or reduced working hours. Most (92%) reported having gained weight since contracting COVID-19 (median weight change +11.5 kg, range -11.5 to +45.3 kg).
UNASSIGNED: Symptoms linked to LC and overweight are diverse and complex. Remote trial delivery enabled rapid recruitment across the UK yet certain groups (e.g. men and those from ethnic minority groups) were under-represented.
UNASSIGNED: ISRCTN registry ( ISRCTN12595520, 25/11/2021).
Long COVID (LC, symptoms lasting 12 weeks or more after a COVID-19 infection) is a poorly understood condition, with no proven treatments. Living with obesity increases the risk of developing LC; symptoms of obesity overlap and aggravate those of LC. The ReDIRECT study tests, in people living with both LC and overweight, whether weight management can reduce LC symptoms. The study involves total diet replacement (with porridge, soups and shakes) for 12 weeks and is delivered remotely, with dietitian support via internet and/or phone. Researchers collected all data via online forms (medical and diet history, COVID-19 infection and vaccination, weight, height, LC history and symptoms, blood pressure, quality of life, and other demographic data). Each participant selected the LC symptom they most wanted to see improve. Participants (n=234) lived across the UK, were mainly women (85%) of white ethnicity (90%), with 13% living in the 20% most deprived areas. Their average age was 46 years old with an average body mass index (BMI) of 35kg/m 2. Diagnosis of LC was mainly by GPs (71%), other healthcare professionals (9%), or self-diagnosed (21%). Participants reported on average 6 symptoms each, identifying fatigue (54%), breathlessness (16%), pain (12%), anxiety/depression (1%) and \"other\" (17%) as the symptom they would most like to see improve. At the start of the study, most (82%) were taking medication, half (57%) reported 1+ other medical conditions. Quality of life was poor, and 20% were on long-term sick leave or reduced working hours. Most (92%) reported gaining weight since contracting COVID-19, on average +11.5 kg. The baseline characteristics of ReDIRECT study participants show that symptoms linked to LC and overweight are diverse and complex. The study being “remote” means that recruitment was rapid and across the UK, yet certain groups (e.g. men and those from ethnic minority groups) were under-represented.
摘要：
■COVID-19感染后症状持续≥12周被称为长COVID（LC），一种病理生理学不清楚且迄今为止没有经过证实的治疗方法的病症。患有肥胖症是LC的危险因素,并且具有可能与LC重叠并加重LC的症状。
■ReDIRECT是一项远程试验，旨在评估体重管理是否可以减轻LC症状。我们招募了LC和BMI>27kg/m2的人。干预是由营养师远程提供的，通过在线数据收集(医疗和饮食史，COVID-19感染和疫苗接种，身体成分,LC病史/症状，血压,生活质量,社会人口统计数据)。参与者自行选择了他们最希望从干预中改善的主要LC症状。
■英格兰（64％）和苏格兰（30％）的参与者（n=234）主要是白人（90％）的女性（85％），13%的人生活在20%最贫困的地区，平均年龄46(SD10)岁，BMI中位数为35kg/m2（IQR32-40）。在开始研究之前,30%的人报告了一种以上的COVID-19感染(82%的人通过一种或多种阳性检测证实)。LC诊断主要由全科医生（71%），其他医疗保健专业人员（9%），或自我诊断（21%）。症状总数的中位数为6（IQR4-8）。自我选择的主要LC症状包括疲劳（54％），呼吸困难(16%)，疼痛（12%），焦虑/抑郁（1%）和“其他”（17%）。在基线,82%的人服用药物，57%的人报告了1+其他医疗条件。生活质量差；20％的人长期病假或减少工作时间。大多数(92%)报告自感染COVID-19以来体重增加(体重变化中位数+11.5公斤，范围-11.5至+45.3kg)。
■与LC和超重相关的症状多种多样且复杂。远程试验交付使整个英国的快速招募成为可能，但某些群体（例如男性和少数族裔群体）的代表性不足。
■ISRCTN注册表（ISRCTN12595520，2021年11月25日）。
长型COVID（LC，COVID-19感染后持续12周或更长时间的症状)是一种知之甚少的疾病，没有经过验证的治疗方法。与肥胖一起生活会增加患LC的风险；肥胖的症状重叠并加重LC的症状。重定向研究测试，同时患有LC和超重的人，体重管理是否可以减轻LC症状。这项研究涉及全面的饮食替代(用粥，汤和奶昔)12周，远程交付，通过互联网和/或电话提供营养师支持。研究人员通过在线表格收集所有数据（医疗和饮食史，COVID-19感染和疫苗接种，体重,高度,LC病史和症状，血压,生活质量,和其他人口统计数据)。每位参与者选择了他们最希望看到改善的LC症状。参与者（n=234）居住在英国各地，主要是白人(90%)的女性(85%)，13%的人生活在20%最贫困的地区。他们的平均年龄为46岁，平均体重指数（BMI）为35kg/m2。LC的诊断主要是由全科医生（71％），其他医疗保健专业人员（9%），或自我诊断（21%）。参与者平均每人报告6种症状，识别疲劳(54%)，呼吸困难(16%)，疼痛（12%），焦虑/抑郁（1％）和“其他”（17％）作为他们最希望看到的症状改善。在研究开始时,大多数（82%）正在服药，一半（57%）报告1+其他医疗条件。生活质量很差，20%的人长期病假或减少工作时间。大多数（92%）报告自感染COVID-19以来体重增加，平均+11.5公斤。ReDIRECT研究参与者的基线特征表明，与LC和超重相关的症状是多样化和复杂的。这项“远程”研究意味着招聘速度很快，而且在英国各地，然而，某些群体(如男子和少数族裔群体)的代表性不足。
■ReDIRECT是一项远程试验，旨在评估体重管理是否可以减轻LC症状。我们招募了LC和BMI>27kg/m2的人。干预是由营养师远程提供的，通过在线数据收集(医疗和饮食史，COVID-19感染和疫苗接种，身体成分,LC病史/症状，血压,生活质量,社会人口统计数据)。参与者自行选择了他们最希望从干预中改善的主要LC症状。
■英格兰（64％）和苏格兰（30％）的参与者（n=234）主要是白人（90％）的女性（85％），13%的人生活在20%最贫困的地区，平均年龄46(SD10)岁，BMI中位数为35kg/m2（IQR32-40）。在开始研究之前,30%的人报告了一种以上的COVID-19感染(82%的人通过一种或多种阳性检测证实)。LC诊断主要由全科医生（71%），其他医疗保健专业人员（9%），或自我诊断（21%）。症状总数的中位数为6（IQR4-8）。自我选择的主要LC症状包括疲劳（54％），呼吸困难(16%)，疼痛（12%），焦虑/抑郁（1%）和“其他”（17%）。在基线,82%的人服用药物，57%的人报告了1+其他医疗条件。生活质量差；20％的人长期病假或减少工作时间。大多数(92%)报告自感染COVID-19以来体重增加(体重变化中位数+11.5公斤，范围-11.5至+45.3kg)。
■与LC和超重相关的症状多种多样且复杂。远程试验交付使整个英国的快速招募成为可能，但某些群体（例如男性和少数族裔群体）的代表性不足。
■ISRCTN注册表（ISRCTN12595520，2021年11月25日）。
长型COVID（LC，COVID-19感染后持续12周或更长时间的症状)是一种知之甚少的疾病，没有经过验证的治疗方法。与肥胖一起生活会增加患LC的风险；肥胖的症状重叠并加重LC的症状。重定向研究测试，同时患有LC和超重的人，体重管理是否可以减轻LC症状。这项研究涉及全面的饮食替代(用粥，汤和奶昔)12周，远程交付，通过互联网和/或电话提供营养师支持。研究人员通过在线表格收集所有数据（医疗和饮食史，COVID-19感染和疫苗接种，体重,高度,LC病史和症状，血压,生活质量,和其他人口统计数据)。每位参与者选择了他们最希望看到改善的LC症状。参与者（n=234）居住在英国各地，主要是白人(90%)的女性(85%)，13%的人生活在20%最贫困的地区。他们的平均年龄为46岁，平均体重指数（BMI）为35kg/m2。LC的诊断主要是由全科医生（71％），其他医疗保健专业人员（9%），或自我诊断（21%）。参与者平均每人报告6种症状，识别疲劳(54%)，呼吸困难(16%)，疼痛（12%），焦虑/抑郁（1％）和“其他”（17％）作为他们最希望看到的症状改善。在研究开始时,大多数（82%）正在服药，一半（57%）报告1+其他医疗条件。生活质量很差，20%的人长期病假或减少工作时间。大多数（92%）报告自感染COVID-19以来体重增加，平均+11.5公斤。ReDIRECT研究参与者的基线特征表明，与LC和超重相关的症状是多样化和复杂的。这项“远程”研究意味着招聘速度很快，而且在英国各地，然而，某些群体(如男子和少数族裔群体)的代表性不足。
