PDF(Pubmed)
Abstract：
UNASSIGNED: In recent years, the frequency of idiopathic peptic ulcers (IPUs) has increased. However, the clinicopathological characteristics of IPU have not been fully elucidated and treatment methods for recurrent and refractory cases have not yet been established.
UNASSIGNED: A man in his forties complained of epigastric discomfort. Esophagogastroduodenoscopy revealed a gastric ulcer in the lesser curvature of the gastric angle. After Helicobacter pylori was eradicated, the gastric ulcer recurred despite the administration of a potassium competitive acid blocker (PCAB), and a diagnosis of IPU was made. Twenty-four-hour intragastric pH monitoring revealed insufficient gastric acid suppression. Misoprostol was added to the patient\'s treatment. Subsequently, the ulcer healed and recurrence was not observed.
UNASSIGNED: For refractory IPU, the evaluation of pathophysiological function through 24-h gastric pH monitoring may lead to the selection of an appropriate treatment. If a proton pump inhibitor and PCAB do not improve the IPU, combination treatment with misoprostol may be considered as an option.
UNASSIGNED: A man in his forties complained of epigastric discomfort. Esophagogastroduodenoscopy revealed a gastric ulcer in the lesser curvature of the gastric angle. After Helicobacter pylori was eradicated, the gastric ulcer recurred despite the administration of a potassium competitive acid blocker (PCAB), and a diagnosis of IPU was made. Twenty-four-hour intragastric pH monitoring revealed insufficient gastric acid suppression. Misoprostol was added to the patient\'s treatment. Subsequently, the ulcer healed and recurrence was not observed.
UNASSIGNED: For refractory IPU, the evaluation of pathophysiological function through 24-h gastric pH monitoring may lead to the selection of an appropriate treatment. If a proton pump inhibitor and PCAB do not improve the IPU, combination treatment with misoprostol may be considered as an option.
摘要：
■近年来，特发性消化性溃疡（IPU）的频率增加。然而,IPU的临床病理特征尚未完全阐明，复发和难治性病例的治疗方法尚未确定。
■一名四十多岁的男子主诉上腹部不适。食管胃十二指肠镜检查显示胃角较小曲率的胃溃疡。根除幽门螺杆菌后,胃溃疡复发，尽管施用钾竞争性酸阻滞剂（PCAB），并对IPU进行了诊断。24小时胃内pH监测显示胃酸抑制不足。在患者的治疗中加入米索前列醇。随后，溃疡愈合，未观察到复发。
■对于耐火IPU，通过24小时胃pH监测评估病理生理功能可能导致选择合适的治疗方法.如果质子泵抑制剂和PCAB不能改善IPU，可考虑与米索前列醇联合治疗.
■一名四十多岁的男子主诉上腹部不适。食管胃十二指肠镜检查显示胃角较小曲率的胃溃疡。根除幽门螺杆菌后,胃溃疡复发，尽管施用钾竞争性酸阻滞剂（PCAB），并对IPU进行了诊断。24小时胃内pH监测显示胃酸抑制不足。在患者的治疗中加入米索前列醇。随后，溃疡愈合，未观察到复发。
■对于耐火IPU，通过24小时胃pH监测评估病理生理功能可能导致选择合适的治疗方法.如果质子泵抑制剂和PCAB不能改善IPU，可考虑与米索前列醇联合治疗.
