PDF(Pubmed)
Abstract：
Schizotypy refers to a set of personality traits that bear resemblance, at subclinical level, to psychosis. Despite evidence of similarity at multiple levels of analysis, direct comparisons of schizotypy and clinical psychotic disorders are rare. Therefore, we used functional magnetic resonance imaging (fMRI) to examine the neural correlates and task-based functional connectivity (psychophysiological interactions; PPI) of smooth pursuit eye movements (SPEM) in patients with recent onset psychosis (ROP; n = 34), participants with high levels of negative (HNS; n = 46) or positive (HPS; n = 41) schizotypal traits, and low-schizotypy control participants (LS; n = 61) using machine-learning. Despite strong previous evidence that SPEM is a highly reliable marker of psychosis, patients and controls could not be significantly distinguished based on SPEM performance or blood oxygen level dependent (BOLD) signal during SPEM. Classification was, however, significant for the right frontal eye field (FEF) seed region in the PPI analyses but not for seed regions in other key areas of the SPEM network. Applying the right FEF classifier to the schizotypal samples yielded decision scores between the LS and ROP groups, suggesting similarities and dissimilarities of the HNS and HPS samples with the LS and ROP groups. The very small difference between groups is inconsistent with previous studies that showed significant differences between patients with ROP and controls in both SPEM performance and underlying neural mechanisms with large effect sizes. As the current study had sufficient power to detect such differences, other reasons are discussed.
摘要：
分裂是指一组相似的人格特质，在亚临床水平，精神病。尽管在多个分析层次上有相似的证据，分裂型和临床精神病性障碍的直接比较是罕见的。因此,我们使用功能磁共振成像（fMRI）来检查神经相关性和基于任务的功能连接（心理生理相互作用；PPI）的平滑追踪眼球运动（SPEM）在最近发作的精神病（ROP；n=34），具有高水平阴性（HNS；n=46）或阳性（HPS；n=41）分裂型性状的参与者，和使用机器学习的低分裂型对照参与者(LS；n=61)。尽管之前有强有力的证据表明SPEM是精神病的高度可靠标记，根据SPEM表现或血氧水平依赖性(BOLD)信号,无法显著区分患者和对照组.分类是，然而,对于PPI分析中的右前眼场（FEF）种子区域，但对于SPEM网络其他关键区域的种子区域则不重要。将正确的FEF分类器应用于分裂型样本，在LS和ROP组之间产生决策评分，提示HNS和HPS样品与LS和ROP组的相似性和差异性。组间非常小的差异与先前的研究不一致，先前的研究表明，ROP患者和对照组在SPEM表现和潜在的神经机制方面存在显着差异，具有较大的效应大小。由于目前的研究有足够的能力来检测这种差异，讨论其他原因。
