PDF(Pubmed)
Abstract：
UNASSIGNED: The relationships between the feeding rhythm, sleep and cognition in Alzheimer\'s disease (AD) are incompletely understood, but meal time could provide an easy-to-implement method of curtailing disease-associated disruptions in sleep and cognition. Furthermore, known sex differences in AD incidence could relate to sex differences in circadian rhythm/sleep/cognition interactions.
UNASSIGNED: The 5xFAD transgenic mouse model of AD and non-transgenic wild-type controls were studied. Both female and male mice were used. Food access was restricted each day to either the 12-h light phase (light-fed groups) or the 12-h dark phase (dark-fed groups). Sleep (electroencephalographic/electromyographic) recording and cognitive behavior measures were collected.
UNASSIGNED: The 5xFAD genotype reduces NREM and REM as well as the number of sleep spindles. In wild-type mice, light-fed groups had disrupted vigilance state amounts, characteristics, and rhythms relative to dark-fed groups. These feeding time differences were reduced in 5xFAD mice. Sex modulates these effects. 5xFAD mice display poorer spatial memory that, in female mice, is curtailed by dark phase feeding. Similarly, female 5xFAD mice have decreased anxiety-associated behavior. These emotional and cognitive measures are correlated with REM amount.
UNASSIGNED: Our study demonstrates that the timing of feeding can alter many aspects of wake, NREM and REM. Unexpectedly, 5xFAD mice are less sensitive to these feeding time effects. 5xFAD mice demonstrate deficits in cognition which are correlated with REM, suggesting that this circadian-timed aspect of sleep may link feeding time and cognition. Sex plays an important role in regulating the impact of feeding time on sleep and cognition in both wild-type and 5xFAD mice, with females showing a greater cognitive response to feeding time than males.
UNASSIGNED: The 5xFAD transgenic mouse model of AD and non-transgenic wild-type controls were studied. Both female and male mice were used. Food access was restricted each day to either the 12-h light phase (light-fed groups) or the 12-h dark phase (dark-fed groups). Sleep (electroencephalographic/electromyographic) recording and cognitive behavior measures were collected.
UNASSIGNED: The 5xFAD genotype reduces NREM and REM as well as the number of sleep spindles. In wild-type mice, light-fed groups had disrupted vigilance state amounts, characteristics, and rhythms relative to dark-fed groups. These feeding time differences were reduced in 5xFAD mice. Sex modulates these effects. 5xFAD mice display poorer spatial memory that, in female mice, is curtailed by dark phase feeding. Similarly, female 5xFAD mice have decreased anxiety-associated behavior. These emotional and cognitive measures are correlated with REM amount.
UNASSIGNED: Our study demonstrates that the timing of feeding can alter many aspects of wake, NREM and REM. Unexpectedly, 5xFAD mice are less sensitive to these feeding time effects. 5xFAD mice demonstrate deficits in cognition which are correlated with REM, suggesting that this circadian-timed aspect of sleep may link feeding time and cognition. Sex plays an important role in regulating the impact of feeding time on sleep and cognition in both wild-type and 5xFAD mice, with females showing a greater cognitive response to feeding time than males.
摘要：
■摄食节奏之间的关系，阿尔茨海默病（AD）的睡眠和认知尚未完全了解，但是进餐时间可以提供一种易于实施的方法来减少与疾病相关的睡眠和认知障碍。此外，已知AD发病率的性别差异可能与昼夜节律/睡眠/认知相互作用的性别差异有关。
■研究了AD的5xFAD转基因小鼠模型和非转基因野生型对照。使用雌性和雄性小鼠。每天将食物的获取限制在12小时的光照阶段（光照组）或12小时的黑暗阶段（黑暗喂养组）。收集睡眠（脑电图/肌电图）记录和认知行为测量。
■5xFAD基因型减少了NREM和REM以及睡眠纺锤体的数量。在野生型小鼠中,轻食组扰乱了警戒状态的数量，特点,和相对于黑暗喂养组的节奏。这些喂食时间差异在5xFAD小鼠中减少。性调节这些效果。5xFAD小鼠显示较差的空间记忆，在雌性老鼠身上，被黑暗阶段喂养所削减。同样，雌性5xFAD小鼠的焦虑相关行为减少。这些情绪和认知测量与REM量相关。
■我们的研究表明，进食时间可以改变唤醒的许多方面，NREM和REM。出乎意料的是,5xFAD小鼠对这些喂食时间效应较不敏感。5xFAD小鼠表现出与REM相关的认知缺陷，这表明睡眠的昼夜节律可能与进食时间和认知有关。在野生型和5xFAD小鼠中，性别在调节喂养时间对睡眠和认知的影响中起着重要作用，女性比男性对进食时间表现出更大的认知反应。
■研究了AD的5xFAD转基因小鼠模型和非转基因野生型对照。使用雌性和雄性小鼠。每天将食物的获取限制在12小时的光照阶段（光照组）或12小时的黑暗阶段（黑暗喂养组）。收集睡眠（脑电图/肌电图）记录和认知行为测量。
■5xFAD基因型减少了NREM和REM以及睡眠纺锤体的数量。在野生型小鼠中,轻食组扰乱了警戒状态的数量，特点,和相对于黑暗喂养组的节奏。这些喂食时间差异在5xFAD小鼠中减少。性调节这些效果。5xFAD小鼠显示较差的空间记忆，在雌性老鼠身上，被黑暗阶段喂养所削减。同样，雌性5xFAD小鼠的焦虑相关行为减少。这些情绪和认知测量与REM量相关。
■我们的研究表明，进食时间可以改变唤醒的许多方面，NREM和REM。出乎意料的是,5xFAD小鼠对这些喂食时间效应较不敏感。5xFAD小鼠表现出与REM相关的认知缺陷，这表明睡眠的昼夜节律可能与进食时间和认知有关。在野生型和5xFAD小鼠中，性别在调节喂养时间对睡眠和认知的影响中起着重要作用，女性比男性对进食时间表现出更大的认知反应。
