PDF(Pubmed)
Abstract：
UNASSIGNED: Angiomatoid fibrous histiocytoma (AFH) is a clinically rare, low-grade malignant soft tissue tumor that occasionally metastasizes. It accounts for 0.3% of all soft tissue tumors and most frequently occurs in the extremities, followed by the trunk, and the head and neck. Primary angiomatoid fibrous histiocytoma (PAFH) of the pulmonary bronchus is rare. In this paper, the clinical and imaging data of a case of PAFH of the pulmonary bronchus are reported, and the literature is reviewed.
UNASSIGNED: A 57-year-old female patient presented with a six-month history of cough without apparent cause, characterized by paroxysmal dry cough, chest tightness, and shortness of breath, which worsened with activity. She did not experience fever, chills, chest pain, hemoptysis, or night sweats. Laboratory tests revealed an elevated C-reactive protein and ferritin levels, while tumor markers such as AFP, CEA, CA199, CA125, CA50, and T-SPOT were negative. A chest CT scan showed bronchial obstruction, atelectasis, and a soft tissue density in the right middle lobe of the lung. The enhanced scan demonstrated uneven enhancement of endobronchial nodules. An 18F-FDG PET/CT scan revealed a nodular soft tissue density shadow in the right lung bronchus with uneven density, clear boundaries, and increased 18F-FDG uptake, with a maximum standard uptake value (SUVmax) of 11.2. Bronchoscopy revealed a nodular or polypoid mass that was yellow and tough. Based on imaging findings, the preoperative diagnosis favored lung cancer. However, the postoperative pathological diagnosis confirmed primary angiomatoid fibrous histiocytoma (PAFH) of the pulmonary bronchus.
UNASSIGNED: The incidence of primary angiomatoid fibrous histiocytoma (PAFH) is very low, and its clinical manifestations and imaging findings lack specificity, with the final diagnosis relying on pathology. PET/CT imaging has a certain value in the diagnosis of PAFH and holds significant application value in preoperative staging, postoperative efficacy evaluation, and follow-up monitoring. In conclusion, this case report further expands the spectrum of lung and bronchial tumors.
UNASSIGNED: A 57-year-old female patient presented with a six-month history of cough without apparent cause, characterized by paroxysmal dry cough, chest tightness, and shortness of breath, which worsened with activity. She did not experience fever, chills, chest pain, hemoptysis, or night sweats. Laboratory tests revealed an elevated C-reactive protein and ferritin levels, while tumor markers such as AFP, CEA, CA199, CA125, CA50, and T-SPOT were negative. A chest CT scan showed bronchial obstruction, atelectasis, and a soft tissue density in the right middle lobe of the lung. The enhanced scan demonstrated uneven enhancement of endobronchial nodules. An 18F-FDG PET/CT scan revealed a nodular soft tissue density shadow in the right lung bronchus with uneven density, clear boundaries, and increased 18F-FDG uptake, with a maximum standard uptake value (SUVmax) of 11.2. Bronchoscopy revealed a nodular or polypoid mass that was yellow and tough. Based on imaging findings, the preoperative diagnosis favored lung cancer. However, the postoperative pathological diagnosis confirmed primary angiomatoid fibrous histiocytoma (PAFH) of the pulmonary bronchus.
UNASSIGNED: The incidence of primary angiomatoid fibrous histiocytoma (PAFH) is very low, and its clinical manifestations and imaging findings lack specificity, with the final diagnosis relying on pathology. PET/CT imaging has a certain value in the diagnosis of PAFH and holds significant application value in preoperative staging, postoperative efficacy evaluation, and follow-up monitoring. In conclusion, this case report further expands the spectrum of lung and bronchial tumors.
摘要：
■血管瘤样纤维组织细胞瘤（AFH）是一种临床罕见的，偶尔转移的低度恶性软组织肿瘤。它占所有软组织肿瘤的0.3％，最常见于四肢，后面是后备箱，头部和颈部。肺支气管的原发性血管瘤样纤维组织细胞瘤（PAFH）很少见。在本文中,报告1例肺支气管PAFH的临床和影像学资料,并对文献进行了综述。
一名57岁女性患者，有6个月的咳嗽史，无明显原因，以阵发性干咳为特征，胸闷,呼吸急促，随着活动的恶化。她没有发烧，发冷,胸痛,咯血,或者盗汗.实验室检测显示C反应蛋白和铁蛋白水平升高,而肿瘤标志物如AFP，CEA,CA199、CA125、CA50和T-SPOT均为阴性。胸部CT扫描显示支气管阻塞,肺不张,和肺右中叶的软组织密度。增强扫描显示支气管内结节不均匀增强。18F-FDGPET/CT扫描显示右肺支气管有结节状软组织密度影，密度不均，清晰的边界,并增加18F-FDG摄取，最大标准摄取值(SUVmax)为11.2。支气管镜检查显示结节状或息肉状肿块，黄色且坚韧。根据影像学检查结果,术前诊断有利于肺癌。然而,术后病理诊断证实肺支气管原发性血管瘤样纤维组织细胞瘤（PAFH）。
■原发性血管瘤样纤维组织细胞瘤（PAFH）的发生率很低，临床表现和影像学表现缺乏特异性,最终诊断依赖于病理学。PET/CT显像对PAFH的诊断具有一定的价值,对术前分期具有重要的应用价值。术后疗效评价,和后续监测。总之,该病例报告进一步扩大了肺和支气管肿瘤的范围。
一名57岁女性患者，有6个月的咳嗽史，无明显原因，以阵发性干咳为特征，胸闷,呼吸急促，随着活动的恶化。她没有发烧，发冷,胸痛,咯血,或者盗汗.实验室检测显示C反应蛋白和铁蛋白水平升高,而肿瘤标志物如AFP，CEA,CA199、CA125、CA50和T-SPOT均为阴性。胸部CT扫描显示支气管阻塞,肺不张,和肺右中叶的软组织密度。增强扫描显示支气管内结节不均匀增强。18F-FDGPET/CT扫描显示右肺支气管有结节状软组织密度影，密度不均，清晰的边界,并增加18F-FDG摄取，最大标准摄取值(SUVmax)为11.2。支气管镜检查显示结节状或息肉状肿块，黄色且坚韧。根据影像学检查结果,术前诊断有利于肺癌。然而,术后病理诊断证实肺支气管原发性血管瘤样纤维组织细胞瘤（PAFH）。
■原发性血管瘤样纤维组织细胞瘤（PAFH）的发生率很低，临床表现和影像学表现缺乏特异性,最终诊断依赖于病理学。PET/CT显像对PAFH的诊断具有一定的价值,对术前分期具有重要的应用价值。术后疗效评价,和后续监测。总之,该病例报告进一步扩大了肺和支气管肿瘤的范围。
