PDF(Pubmed)
Abstract：
Bone defects caused by tumors, osteoarthritis, and osteoporosis attract great attention. Because of outstanding biocompatibility, osteogenesis promotion, and less secondary infection incidence ratio, stimuli-responsive biomaterials are increasingly used to manage this issue. These biomaterials respond to certain stimuli, changing their mechanical properties, shape, or drug release rate accordingly. Thereafter, the activated materials exert instructive or triggering effects on cells and tissues, match the properties of the original bone tissues, establish tight connection with ambient hard tissue, and provide suitable mechanical strength. In this review, basic definitions of different categories of stimuli-responsive biomaterials are presented. Moreover, possible mechanisms, advanced studies, and pros and cons of each classification are discussed and analyzed. This review aims to provide an outlook on the future developments in stimuli-responsive biomaterials.
摘要：
肿瘤引起的骨缺损,骨关节炎,骨质疏松症引起了极大的关注。由于突出的生物相容性，成骨促进,继发感染发生率较低，刺激响应的生物材料越来越多地用于管理这个问题。这些生物材料对某些刺激有反应,改变它们的机械性能，形状,或相应的药物释放速率。此后,激活的物质对细胞和组织发挥指导或触发作用，匹配原始骨组织的特性，与周围的硬组织建立紧密的连接，并提供合适的机械强度。在这次审查中,提出了不同类别的刺激响应生物材料的基本定义。此外，可能的机制，高级研究,并对每种分类的利弊进行了讨论和分析。这篇综述旨在对刺激响应型生物材料的未来发展进行展望。
