PDF(Pubmed)
Abstract：
Iron deficiency is a common and independent predictor of adverse outcomes in patients with heart failure. The implications of iron deficiency in patients implanted with a left ventricular assist device (LVAD) are less established. This review recaps data on the prevalence, characteristics and impact of Iron deficiency in the LVAD population. A systematic search yielded eight studies involving 517 LVAD patients, with iron deficiency prevalence ranging from 40% to 82%. IV iron repletion was not associated with adverse events and effectively resolved iron deficiency in most patients. However, the effects of iron deficiency and iron repletion on post-implant survival and exercise capacity remain unknown. Although iron deficiency is highly prevalent in LVAD patients, its true prevalence and adverse effects may be misestimated due to inexact diagnostic criteria. Future randomised controlled trials on IV iron treatment in LVAD patients are warranted to clarify the significance of this common comorbidity.
摘要：
铁缺乏是心力衰竭患者不良结局的常见且独立的预测因素。植入左心室辅助装置（LVAD）的患者缺铁的影响尚不明确。这篇综述概述了患病率的数据，LVAD人群铁缺乏的特点和影响。一项系统的搜索产生了8项研究，涉及517名LVAD患者，缺铁患病率从40%到82%不等。在大多数患者中，静脉补铁与不良事件无关，并有效解决了铁缺乏。然而,铁缺乏和铁补充对植入后生存和运动能力的影响尚不清楚.尽管在LVAD患者中缺铁率很高,由于诊断标准不准确,其真实患病率和不良反应可能被错误估计.有必要对LVAD患者进行IV铁治疗的未来随机对照试验，以阐明这种常见合并症的重要性。
