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Abstract：
OBJECTIVE: The aim of the study was to analyze the clinical data of patients with chronic obstructive pulmonary disease and obstructive sleep apnea overlap syndrome (OS) during hospitalization and to evaluate the risk factors of patients treated with Non-Invasive Ventilation (NIV).
METHODS: Demographic and clinical data of patients with confirmed OS during hospitalization were retrospectively collected. The patients were divided into two groups according to whether noninvasive ventilator was used during hospitalization, including OS treated with NIV (244 cases) and OS without NIV (239 cases). The t-test, χ 2 test, and Kaplan-Meier curve were used to compare the two groups, and multiple logistic regression was used to analyze the risk factors of NIV in patients with OS.
RESULTS: Compared with the OS group without NIV, the pulmonary hypertension, lymphocyte count, and left ventricular ejection fraction% of OS patients with NIV were lower, whereas PCO2, uric acid, C-reactive protein, procalcitonin, and N-terminal pro-B-type natriuretic peptide were higher, with statistical differences (P < 0.05). During hospitalization and follow-up, OS patients with NIV had a longer hospital stay (P < 0.001), and there was no significant difference in the rate of readmission within 28 days. The logistic regression analysis showed that the history of diuretic use, previous history of noninvasive ventilator use, and ischemic heart disease were independent risk factors for NIV treatment in OS patients during hospitalization.
CONCLUSIONS: Patients with OS undergoing NIV during hospitalization exhibited more severe overall illness and had prolonged hospital stays compared to OS patients not receiving NIV. History of diuretic use, history of NIV use, and ischemic heart disease are independent risk factors for NIV treatment in OS patients during hospitalization.
METHODS: Demographic and clinical data of patients with confirmed OS during hospitalization were retrospectively collected. The patients were divided into two groups according to whether noninvasive ventilator was used during hospitalization, including OS treated with NIV (244 cases) and OS without NIV (239 cases). The t-test, χ 2 test, and Kaplan-Meier curve were used to compare the two groups, and multiple logistic regression was used to analyze the risk factors of NIV in patients with OS.
RESULTS: Compared with the OS group without NIV, the pulmonary hypertension, lymphocyte count, and left ventricular ejection fraction% of OS patients with NIV were lower, whereas PCO2, uric acid, C-reactive protein, procalcitonin, and N-terminal pro-B-type natriuretic peptide were higher, with statistical differences (P < 0.05). During hospitalization and follow-up, OS patients with NIV had a longer hospital stay (P < 0.001), and there was no significant difference in the rate of readmission within 28 days. The logistic regression analysis showed that the history of diuretic use, previous history of noninvasive ventilator use, and ischemic heart disease were independent risk factors for NIV treatment in OS patients during hospitalization.
CONCLUSIONS: Patients with OS undergoing NIV during hospitalization exhibited more severe overall illness and had prolonged hospital stays compared to OS patients not receiving NIV. History of diuretic use, history of NIV use, and ischemic heart disease are independent risk factors for NIV treatment in OS patients during hospitalization.
摘要：
目的：本研究旨在分析慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停重叠综合征(OS)患者住院期间的临床资料，并评估非侵入性通气(NIV)患者的危险因素。
方法：回顾性收集住院期间OS确诊患者的人口统计学和临床资料。根据患者住院期间是否使用无创呼吸机分为两组,包括OS采用NIV治疗（244例）和OS不采用NIV治疗（239例）。t检验,χ2检验，采用Kaplan-Meier曲线比较两组,采用多因素logistic回归分析OS患者发生NIV的危险因素。
结果：与无NIV的OS组相比，肺动脉高压，淋巴细胞计数,NIVOS患者的左心室射血分数%较低，而PCO2，尿酸，C反应蛋白,降钙素原,N末端B型利钠肽前体较高，具有统计学差异(P<0.05)。在住院和随访期间，OS患者NIV住院时间较长(P<0.001),28天内再入院率无显著差异。logistic回归分析显示,利尿剂使用史,以前的无创呼吸机使用史，和缺血性心脏病是OS患者住院期间NIV治疗的独立危险因素。
结论：与未接受NIV的OS患者相比，住院期间接受NIV的OS患者表现出更严重的整体疾病，并且住院时间延长。使用利尿剂的历史，NIV使用的历史，和缺血性心脏病是OS患者住院期间NIV治疗的独立危险因素。
方法：回顾性收集住院期间OS确诊患者的人口统计学和临床资料。根据患者住院期间是否使用无创呼吸机分为两组,包括OS采用NIV治疗（244例）和OS不采用NIV治疗（239例）。t检验,χ2检验，采用Kaplan-Meier曲线比较两组,采用多因素logistic回归分析OS患者发生NIV的危险因素。
结果：与无NIV的OS组相比，肺动脉高压，淋巴细胞计数,NIVOS患者的左心室射血分数%较低，而PCO2，尿酸，C反应蛋白,降钙素原,N末端B型利钠肽前体较高，具有统计学差异(P<0.05)。在住院和随访期间，OS患者NIV住院时间较长(P<0.001),28天内再入院率无显著差异。logistic回归分析显示,利尿剂使用史,以前的无创呼吸机使用史，和缺血性心脏病是OS患者住院期间NIV治疗的独立危险因素。
结论：与未接受NIV的OS患者相比，住院期间接受NIV的OS患者表现出更严重的整体疾病，并且住院时间延长。使用利尿剂的历史，NIV使用的历史，和缺血性心脏病是OS患者住院期间NIV治疗的独立危险因素。
