PDF(Pubmed)
Abstract：
Introduction: The mechanical properties of the sclera are related to its structural function, and changes to these properties are believed to contribute to pathologies such as myopia. Air-puff deformation imaging is a tool that uses an imaging system coupled with an air-puff excitation source to induce and measure deformation in a tissue in vivo. Typically used for the study of the cornea\'s mechanical properties and IOP, this tool has been proposed as a method to evaluate scleral stiffness. Methods: In this work, we present a computational model of the rabbit eye to assess scleral deformation under air-puff. Parametric studies were conducted to evaluate the effects of material properties, intraocular pressure, and other parameters on the deformation response. Output from the model was also compared to experimental measurements of air-puff deformation in rabbit eyes under varying IOP. Results: Central deformation response was found to be most influenced by material properties of the sclera (at site of air-puff and posterior), thickness, and IOP, whereas deformation profile was most influenced by material properties. Experimental and simulated IOP dependence were found to be similar (RMSE = 0.13 mm). Discussion: Scleral APDI could be a useful tool for quick in vivo assessment of scleral stiffness.
摘要：
简介:巩膜的力学性能与其结构功能有关,并且这些特性的改变被认为会导致诸如近视的病理。空气抽吸变形成像是使用与空气抽吸激发源耦合的成像系统来引起和测量体内组织中的变形的工具。通常用于研究角膜的机械性能和眼压，该工具已被提出作为评估巩膜刚度的方法。方法：在这项工作中，我们提出了兔眼的计算模型，以评估空气抽吸下巩膜的变形。进行了参数研究以评估材料特性的影响，眼内压,等参数对变形响应的影响。还将模型的输出与在不同IOP下的兔眼中的空气抽吸变形的实验测量结果进行了比较。结果：发现中央变形响应受巩膜材料特性的影响最大（在空气吹气部位和后部），厚度,和IOP,而变形轮廓受材料特性影响最大。发现实验和模拟的IOP依赖性相似(RMSE=0.13mm)。讨论:巩膜APDI可以是用于快速体内评估巩膜硬度的有用工具。
