UNASSIGNED: Liposomal-naringenin was synthesized by thin-film hydration and extrusion and was characterized by spectrophotometry, dynamic light scattering, and zeta potential. The effects of free-from naringenin and liposomal-naringenin were evaluated toward MDA-MB-231 cell viability when combined with varying doses of radiation. Additionally, cell growth patterns, morphology, and colony formation were evaluated.
UNASSIGNED: The analysis demonstrated IC50 values of 387.5 and 546.6 µg/ml for naringenin and liposomal-naringenin, respectively. Naringenin and liposomal-naringenin significantly lowered cell viability, proliferation, and colony formation dose-dependently, as compared to radiation in isolation.
UNASSIGNED: The findings presented herein concur with previous accounts of the radiosensitizing potential of naringenin and further highlight the considerable biomedical application of liposomal-naringenin within the realm of radiotherapy.
■脂质体-柚皮素是通过薄膜水合和挤出合成的,并通过分光光度法进行了表征,动态光散射,和zeta电位。当与不同剂量的辐射组合时,评估了游离柚皮素和脂质体-柚皮素对MDA-MB-231细胞活力的影响。此外,细胞生长模式,形态学,和集落形成进行了评价。
■分析显示柚皮素和脂质体-柚皮素的IC50值为387.5和546.6µg/ml,分别。柚皮素和脂质体柚皮素显著降低细胞活力,扩散,和集落形成剂量依赖性,与孤立的辐射相比。
本文呈现的发现与先前关于柚皮素的放射增敏潜力的描述一致,并且进一步突出了脂质体-柚皮素在放射治疗领域中的相当大的生物医学应用。