PDF(Pubmed)
Abstract：
OBJECTIVE: The research aimed to determine the importance of vitamin D and markers of bone metabolism in the overall assessment of bone mineralization during a child\'s first year of life.
METHODS: The 198 children were selected by screening all infants seen at our pediatric clinic over a 2-year period from 2020-2022 and including those who met the eligibility criteria of being aged 0 to 1 year, healthy with no chronic conditions, and not on vitamin D supplementation. Children were divided into 3 groups depending on the content of vitamin D in the blood serum: sufficient, insufficient, and deficient. The markers of bone tissue status included: markers of mineral metabolism (calcium, phosphorus, parathyroid hormone, calcitonin), a marker of bone formation (osteocalcin), resorption marker (deoxypyridinoline). Laboratory values were obtained at the time of study enrollment during the initial study visit. Labs were not repeated during the course of the study.
RESULTS: A quarter of the infants exhibited vitamin D deficiency at enrollment with serum 25OHD concentrations below 20 ng/mL, which showed a positive correlation with serum calcium and phosphorus -concentrations and a negative correlation with PTH, while osteocalcin and deoxypyridinoline concentrations remained consistent regardless of vitamin D status.
CONCLUSIONS: The study\'s practical significance allows for the recommendation of using vitamin D -concentrations as a marker to detect bone formation and mineral metabolism disorders in children during their first year of life. By identifying and addressing these issues early on, the health care system aims to ensure better musculoskeletal health for children.
METHODS: The 198 children were selected by screening all infants seen at our pediatric clinic over a 2-year period from 2020-2022 and including those who met the eligibility criteria of being aged 0 to 1 year, healthy with no chronic conditions, and not on vitamin D supplementation. Children were divided into 3 groups depending on the content of vitamin D in the blood serum: sufficient, insufficient, and deficient. The markers of bone tissue status included: markers of mineral metabolism (calcium, phosphorus, parathyroid hormone, calcitonin), a marker of bone formation (osteocalcin), resorption marker (deoxypyridinoline). Laboratory values were obtained at the time of study enrollment during the initial study visit. Labs were not repeated during the course of the study.
RESULTS: A quarter of the infants exhibited vitamin D deficiency at enrollment with serum 25OHD concentrations below 20 ng/mL, which showed a positive correlation with serum calcium and phosphorus -concentrations and a negative correlation with PTH, while osteocalcin and deoxypyridinoline concentrations remained consistent regardless of vitamin D status.
CONCLUSIONS: The study\'s practical significance allows for the recommendation of using vitamin D -concentrations as a marker to detect bone formation and mineral metabolism disorders in children during their first year of life. By identifying and addressing these issues early on, the health care system aims to ensure better musculoskeletal health for children.
摘要：
目的：该研究旨在确定维生素D和骨代谢标志物在儿童第一年骨矿化总体评估中的重要性。
方法：通过筛查2020-2022年2年内在我们儿科诊所看到的所有婴儿，选择了198名儿童，包括符合0至1岁资格标准的儿童。健康，没有慢性疾病，而不是补充维生素D。根据血清中维生素D的含量将儿童分为3组：足够，不足,和不足。骨组织状态的标志物包括：矿物质代谢的标志物（钙，磷，甲状旁腺激素,降钙素），骨形成的标记（骨钙蛋白），再吸收标记（脱氧吡啶啉）。在初次研究访视期间,在研究登记时获得实验室值。在研究过程中没有重复实验。
结果：四分之一的婴儿在入学时表现出维生素D缺乏，血清25OHD浓度低于20ng/mL，与血清钙、磷浓度呈正相关，与PTH呈负相关，而无论维生素D状态如何，骨钙蛋白和脱氧吡啶啉浓度保持一致。
结论：这项研究的实际意义允许建议使用维生素D浓度作为标记来检测儿童第一年的骨形成和矿物质代谢紊乱。通过尽早识别和解决这些问题，卫生保健系统旨在确保儿童更好的肌肉骨骼健康。
方法：通过筛查2020-2022年2年内在我们儿科诊所看到的所有婴儿，选择了198名儿童，包括符合0至1岁资格标准的儿童。健康，没有慢性疾病，而不是补充维生素D。根据血清中维生素D的含量将儿童分为3组：足够，不足,和不足。骨组织状态的标志物包括：矿物质代谢的标志物（钙，磷，甲状旁腺激素,降钙素），骨形成的标记（骨钙蛋白），再吸收标记（脱氧吡啶啉）。在初次研究访视期间,在研究登记时获得实验室值。在研究过程中没有重复实验。
结果：四分之一的婴儿在入学时表现出维生素D缺乏，血清25OHD浓度低于20ng/mL，与血清钙、磷浓度呈正相关，与PTH呈负相关，而无论维生素D状态如何，骨钙蛋白和脱氧吡啶啉浓度保持一致。
结论：这项研究的实际意义允许建议使用维生素D浓度作为标记来检测儿童第一年的骨形成和矿物质代谢紊乱。通过尽早识别和解决这些问题，卫生保健系统旨在确保儿童更好的肌肉骨骼健康。
