PDF(Pubmed)
Abstract：
UNASSIGNED: Interstitial lung diseases (ILDs) are a group of pulmonary disorders affecting the lung\'s structure. Acute exacerbation of ILD (AE-ILD) following medical procedures is a significant clinical concern. Lung cryoprobe transbronchial biopsy (cryobiopsy) is a relatively new diagnostic technique for ILD, but data on AE-ILD post-cryobiopsy is limited. This study aims to fill this gap by examining the prevalence, risk factors, and outcomes of AE-ILD following cryobiopsy.
UNASSIGNED: This multicenter retrospective study analyzed data from patients who underwent cryobiopsy for ILD diagnosis at three U.S. institutions between January 2014 and August 2022. The study included patients over 18 years with confirmed or suspected ILD, categorized into those who experienced AE-ILD post-cryobiopsy and those who did not.
UNASSIGNED: Out of 111 patients, 3.6% experienced AE-ILD, with a 50% mortality rate in these cases. The study cohort was predominantly white, with a median age of 69.0 years. Common comorbidities included tobacco use and hypertension. Patients who developed AE-ILD had an increased median number of biopsies. The overall 30-day mortality was 1.8%. Overall complication rate was 32%, including pneumonia, pneumothorax, AE-ILD, and bleeding requiring intervention. The study findings suggest that bronchoscopic cryobiopsy may be associated with lower overall mortality, particularly in patients with compromised lung function.
UNASSIGNED: This study provides significant insights into AE-ILD following cryobiopsy, underscoring the need for careful patient selection and procedural assessment. While cryobiopsy may offer a safer alternative to surgical lung biopsy in specific patient cohorts, the elevated risk of AE-ILD necessitates further research to optimize patient outcomes and procedural safety.
UNASSIGNED: This multicenter retrospective study analyzed data from patients who underwent cryobiopsy for ILD diagnosis at three U.S. institutions between January 2014 and August 2022. The study included patients over 18 years with confirmed or suspected ILD, categorized into those who experienced AE-ILD post-cryobiopsy and those who did not.
UNASSIGNED: Out of 111 patients, 3.6% experienced AE-ILD, with a 50% mortality rate in these cases. The study cohort was predominantly white, with a median age of 69.0 years. Common comorbidities included tobacco use and hypertension. Patients who developed AE-ILD had an increased median number of biopsies. The overall 30-day mortality was 1.8%. Overall complication rate was 32%, including pneumonia, pneumothorax, AE-ILD, and bleeding requiring intervention. The study findings suggest that bronchoscopic cryobiopsy may be associated with lower overall mortality, particularly in patients with compromised lung function.
UNASSIGNED: This study provides significant insights into AE-ILD following cryobiopsy, underscoring the need for careful patient selection and procedural assessment. While cryobiopsy may offer a safer alternative to surgical lung biopsy in specific patient cohorts, the elevated risk of AE-ILD necessitates further research to optimize patient outcomes and procedural safety.
摘要：
■间质性肺病(ILD)是一组影响肺部结构的肺部疾病。医疗程序后ILD的急性恶化（AE-ILD）是一个重要的临床问题。肺冷冻探头经支气管活检（冷冻活检）是一种相对较新的ILD诊断技术，但冷冻后的AE-ILD数据有限.这项研究旨在通过检查患病率来填补这一空白，危险因素，和冷冻活检后AE-ILD的结果。
这项多中心回顾性研究分析了2014年1月至2022年8月在美国三家机构接受冷冻活检以诊断ILD的患者的数据。该研究包括18岁以上确诊或疑似ILD的患者，将经历过AE-ILD的人分为冷冻后和没有经历过的人。
■在111名患者中，3.6%有AE-ILD经验，这些病例的死亡率为50%。研究队列主要是白人，平均年龄为69.0岁。常见的合并症包括烟草使用和高血压。发生AE-ILD的患者活检的中位数增加。总体30天死亡率为1.8%。总并发症发生率为32%,包括肺炎,气胸,AE-ILD,出血需要干预。研究结果表明，支气管镜冷冻活检可能与较低的总死亡率有关。尤其是肺功能受损的患者。
■这项研究为冷冻活检后的AE-ILD提供了重要的见解，强调需要仔细的患者选择和程序评估。虽然冷冻活检可能在特定患者队列中提供比外科肺活检更安全的替代方案，AE-ILD风险升高,需要进一步研究以优化患者结局和手术安全性.
这项多中心回顾性研究分析了2014年1月至2022年8月在美国三家机构接受冷冻活检以诊断ILD的患者的数据。该研究包括18岁以上确诊或疑似ILD的患者，将经历过AE-ILD的人分为冷冻后和没有经历过的人。
■在111名患者中，3.6%有AE-ILD经验，这些病例的死亡率为50%。研究队列主要是白人，平均年龄为69.0岁。常见的合并症包括烟草使用和高血压。发生AE-ILD的患者活检的中位数增加。总体30天死亡率为1.8%。总并发症发生率为32%,包括肺炎,气胸,AE-ILD,出血需要干预。研究结果表明，支气管镜冷冻活检可能与较低的总死亡率有关。尤其是肺功能受损的患者。
■这项研究为冷冻活检后的AE-ILD提供了重要的见解，强调需要仔细的患者选择和程序评估。虽然冷冻活检可能在特定患者队列中提供比外科肺活检更安全的替代方案，AE-ILD风险升高,需要进一步研究以优化患者结局和手术安全性.
