PDF(Pubmed)
Abstract：
Worldwide increase of head and neck cancers ranks these malignancies among top causes of cancer in human population. Radiation induced skin injury (RISI) is one of the major side effects of radiotherapy (RT). Skin of the neck is exposed to radiation due to necessity of therapeutic or prophylactic (elective) irradiation of neck lymph nodes and target organs, including the larynx and hypopharynx. The location of the neck exposes these regions of the skin to various additional exposomes such as ultraviolet radiation (UVR), pollution and cigarette smoke. There are many controversies or inconsistencies regarding RISI, from molecular aspects and therapy to terminology. There is lack of high-quality and large-sample studies in both forms of RISI: acute (aRISI) and chronic (cRISI). Finally, no gold standards in the management of aRISI and cRISI have been established yet. In this article, the authors discuss the pathogenesis, clinical picture, prevention and clinical interventions and present a proposed treatment algorithm.
摘要：
在全球范围内，头颈癌的增加将这些恶性肿瘤列为人类人群中癌症的主要原因。放射性皮肤损伤（RISI）是放疗（RT）的主要副作用之一。由于需要对颈部淋巴结和靶器官进行治疗性或预防性（选择性）照射，因此颈部皮肤暴露于辐射。包括喉和下咽.颈部的位置使皮肤的这些区域暴露于各种额外的暴露,例如紫外线辐射(UVR),污染和香烟烟雾。关于RISI有很多争议或不一致之处，从分子方面和治疗到术语。在两种形式的RISI中都缺乏高质量和大样本的研究：急性（aRISI）和慢性（cRISI）。最后,目前还没有建立ARISI和CRISI管理的黄金标准。在这篇文章中,作者讨论了发病机理，临床图片，预防和临床干预，并提出了一种建议的治疗算法。
