PDF(Pubmed)
Abstract：
The Comparative Genome Dashboard is a web-based software tool for interactive exploration of the similarities and differences in gene functions between organisms. It provides a high-level graphical survey of cellular functions, and enables the user to drill down to examine subsystems of interest in greater detail. At its highest level the Comparative Dashboard contains panels for cellular systems such as biosynthesis, energy metabolism, transport, and response to stimulus. Each panel contains a set of bar graphs that plot the numbers of compounds or gene products for each organism across a set of subsystems of that panel. Users can interactively drill down to focus on subsystems of interest and see grids of compounds produced or consumed by each organism, specific GO term assignments, pathway diagrams, and links to more detailed comparison pages. For example, the dashboard enables users to compare the cofactors that a set of organisms can synthesize, the metal ions that they are able to transport, their DNA damage repair capabilities, their biofilm-formation genes, and their viral response proteins. The dashboard enables users to quickly perform comprehensive comparisons at varying levels of detail.
摘要：
比较基因组仪表板是一个基于网络的软件工具，用于交互式探索生物体之间基因功能的相似性和差异。它提供了细胞功能的高级图形调查，并使用户能够向下钻取以更详细地检查感兴趣的子系统。在其最高水平的比较仪表板包含面板的细胞系统，如生物合成，能量代谢，运输,对刺激的反应。每个面板包含一组条形图，这些条形图绘制了该面板的一组子系统中每种生物体的化合物或基因产物的数量。用户可以交互地向下钻取，专注于感兴趣的子系统，并看到每个生物体产生或消耗的化合物网格，具体的GO学期作业，路径图，和链接到更详细的比较页面。例如,仪表板使用户能够比较一组生物体可以合成的辅因子，它们能够运输的金属离子，他们的DNA损伤修复能力，它们的生物膜形成基因，和它们的病毒反应蛋白。仪表板使用户能够在不同的细节级别快速执行全面的比较。
