PDF(Pubmed)
Abstract：
UNASSIGNED: Due to decreased manual dexterity, a lack of motivation, and difficulty on the part of the caregiver conducting efficient oral hygiene measures at home, patients with Down syndrome (DS) are badly affected. The objective of this study is to compare the efficacy of 0.1% octenidine (OCT) hydrochloride and 0.12% chlorhexidine (CHX) gluconate on plaque control and oxidative stress in institutionalized children with DS.
UNASSIGNED: In 20 children, salivary samples were collected for analysis of the inflammatory marker high-sensitive C-reactive protein (hsCRP) and oxidative stress markers, specifically malondialdehyde (MDA). Plaque index (PlI) and gingival index (GI) were scored. After oral prophylaxis, the participants were randomly assigned to two groups, each consisting of 10 individuals (octenidol and CHX). Salivary oxidative stress marker assays were carried out using a modified version of Yagi\'s (1984) method, and absorbance was measured at 540 nm using an ultraviolet-visible spectrophotometer at 535 nm. hsCRP assays were conducted via latex turbidimetric immunoassay.
UNASSIGNED: On comparison between the two groups, the OCT group showed a statistically significant reduction in GI, PlI, and MDA values (p < 0.05).
UNASSIGNED: It was seen that the use of 0.1% OCT hydrochloride could facilitate the maintenance of good oral hygiene and periodontal status, especially in patients with motor difficulties.
UNASSIGNED: PMS/IEC/2016/02.
UNASSIGNED: Raj AS, George S, S A, et al. Comparing the Effectiveness of Octenidine Hydrochloride and Chlorhexidine Gluconate Mouthrinses in Reducing Plaque and Oxidative Stress in Institutionalized Children with Down Syndrome. Int J Clin Pediatr Dent 2024;17(4):437-441.
UNASSIGNED: In 20 children, salivary samples were collected for analysis of the inflammatory marker high-sensitive C-reactive protein (hsCRP) and oxidative stress markers, specifically malondialdehyde (MDA). Plaque index (PlI) and gingival index (GI) were scored. After oral prophylaxis, the participants were randomly assigned to two groups, each consisting of 10 individuals (octenidol and CHX). Salivary oxidative stress marker assays were carried out using a modified version of Yagi\'s (1984) method, and absorbance was measured at 540 nm using an ultraviolet-visible spectrophotometer at 535 nm. hsCRP assays were conducted via latex turbidimetric immunoassay.
UNASSIGNED: On comparison between the two groups, the OCT group showed a statistically significant reduction in GI, PlI, and MDA values (p < 0.05).
UNASSIGNED: It was seen that the use of 0.1% OCT hydrochloride could facilitate the maintenance of good oral hygiene and periodontal status, especially in patients with motor difficulties.
UNASSIGNED: PMS/IEC/2016/02.
UNASSIGNED: Raj AS, George S, S A, et al. Comparing the Effectiveness of Octenidine Hydrochloride and Chlorhexidine Gluconate Mouthrinses in Reducing Plaque and Oxidative Stress in Institutionalized Children with Down Syndrome. Int J Clin Pediatr Dent 2024;17(4):437-441.
摘要：
■由于手灵活性下降，缺乏动力，以及护理人员难以在家中进行有效的口腔卫生措施，唐氏综合征（DS）患者受到严重影响。这项研究的目的是比较0.1％奥替尼定（OCT）盐酸盐和0.12％氯己定（CHX）葡萄糖酸盐对DS住院儿童的斑块控制和氧化应激的疗效。
■在20个孩子中，收集唾液样本用于分析炎症标志物高敏C反应蛋白（hsCRP）和氧化应激标志物，特别是丙二醛（MDA）。对菌斑指数（PlI）和牙龈指数（GI）进行评分。口服预防后，参与者被随机分为两组，每个由10个人组成（辛烯多和CHX）。唾液氧化应激标志物测定使用Yagi(1984)方法的修改版本进行，使用紫外-可见分光光度计在540nm测量吸光度。hsCRP测定通过胶乳比浊法免疫测定进行。
■两组比较,OCT组的GI有统计学意义的显著减少,PLI,和MDA值(p<0.05)。
■可以看出，使用0.1％的盐酸OCT可以促进保持良好的口腔卫生和牙周状态，尤其是运动困难的患者。
■PMS/IEC/2016/02。
■RajAS,乔治·S,SA,etal.比较盐酸奥替尼定和葡萄糖酸氯己定漱口水在减少唐氏综合征住院儿童斑块和氧化应激中的有效性。IntJClinPediatrDent2024；17(4)：437-441。
■在20个孩子中，收集唾液样本用于分析炎症标志物高敏C反应蛋白（hsCRP）和氧化应激标志物，特别是丙二醛（MDA）。对菌斑指数（PlI）和牙龈指数（GI）进行评分。口服预防后，参与者被随机分为两组，每个由10个人组成（辛烯多和CHX）。唾液氧化应激标志物测定使用Yagi(1984)方法的修改版本进行，使用紫外-可见分光光度计在540nm测量吸光度。hsCRP测定通过胶乳比浊法免疫测定进行。
■两组比较,OCT组的GI有统计学意义的显著减少,PLI,和MDA值(p<0.05)。
■可以看出，使用0.1％的盐酸OCT可以促进保持良好的口腔卫生和牙周状态，尤其是运动困难的患者。
■PMS/IEC/2016/02。
■RajAS,乔治·S,SA,etal.比较盐酸奥替尼定和葡萄糖酸氯己定漱口水在减少唐氏综合征住院儿童斑块和氧化应激中的有效性。IntJClinPediatrDent2024；17(4)：437-441。
