PDF(Pubmed)
Abstract：
UNASSIGNED: Meniere\'s disease (MD) is an ear-related vestibular disorder accompanied by vertigo, hearing loss, and tinnitus. The anatomical structure and spatial position of the semicircular canals are important for understanding vestibular function and disease; however, research on MD and the effect of anatomical changes in the semicircular canals is limited. This study explored the relationship between the spatial location of the semicircular canals and MD using ultra-high-resolution computed tomography (U-HRCT) and intelligent segmentation.
UNASSIGNED: Isotropic U-HRCT images obtained from patients with MD and healthy controls (HCs) were retrospectively analyzed. We extracted the semicircular canal structures and extracted their skeleton. The plane of the skeleton of each semicircular canal was fitted separately. The mutual angles between the semicircular canals, and the angles between each semicircular canal and each plane of the coordinate system were measured.
UNASSIGNED: Among 45 MD-affected ears (MDAEs), 33 MD-healthy ears (MDHEs), and 45 HC ears, the angle between the superior and lateral semicircular canals (LSCs) and the angle between the superior and posterior semicircular canals (PSCs) were larger in the MDAE and MDHE groups than the HC group (P<0.01), while the angle between the posterior and LSCs was smaller in the MDAE group than the HC group (P<0.001). The angles between the superior and PSCs and coronal plane (CP) of the coordinate system were significantly smaller in the MDAE and MDHE groups than the HC group (P<0.01); however, the angles between the LSC and axial plane and CP were significantly larger in the MDAE and MDHE groups than the HC group (P<0.001).
UNASSIGNED: Spatial position changes in the semicircular canals may be the anatomical basis of MD.
UNASSIGNED: Isotropic U-HRCT images obtained from patients with MD and healthy controls (HCs) were retrospectively analyzed. We extracted the semicircular canal structures and extracted their skeleton. The plane of the skeleton of each semicircular canal was fitted separately. The mutual angles between the semicircular canals, and the angles between each semicircular canal and each plane of the coordinate system were measured.
UNASSIGNED: Among 45 MD-affected ears (MDAEs), 33 MD-healthy ears (MDHEs), and 45 HC ears, the angle between the superior and lateral semicircular canals (LSCs) and the angle between the superior and posterior semicircular canals (PSCs) were larger in the MDAE and MDHE groups than the HC group (P<0.01), while the angle between the posterior and LSCs was smaller in the MDAE group than the HC group (P<0.001). The angles between the superior and PSCs and coronal plane (CP) of the coordinate system were significantly smaller in the MDAE and MDHE groups than the HC group (P<0.01); however, the angles between the LSC and axial plane and CP were significantly larger in the MDAE and MDHE groups than the HC group (P<0.001).
UNASSIGNED: Spatial position changes in the semicircular canals may be the anatomical basis of MD.
摘要：
■梅尼埃病（MD）是一种与耳朵相关的前庭疾病，伴有眩晕，听力损失,还有耳鸣.半规管的解剖结构和空间位置对于了解前庭功能和疾病很重要；然而，关于MD和半规管解剖学变化的影响的研究是有限的。本研究使用超高分辨率计算机断层扫描（U-HRCT）和智能分割探索了半规管的空间位置与MD之间的关系。
■回顾性分析从MD患者和健康对照（HC）获得的各向同性U-HRCT图像。我们提取了半规管结构并提取了它们的骨架。每个半规管的骨架平面分别安装。半圆形运河之间的相互角度，并测量了每个半规管与坐标系每个平面之间的角度。
■在45只受MD影响的耳朵（MDAE）中，33只MD健康的耳朵（MDHE），和45只HC耳朵，MDAE和MDHE组的上半规管与外侧半规管（LSCs）之间的角度和上半规管与后半规管（PSC）之间的角度均大于HC组（P<0.01），MDAE组后端与LSCs之间的夹角小于HC组（P<0.001）。MDAE组和MDHE组的上、PSC与坐标系冠状面(CP)的夹角明显小于HC组(P<0.01);MDAE和MDHE组的LSC与轴向平面和CP之间的角度明显大于HC组（P<0.001）。
■半规管的空间位置变化可能是MD的解剖学基础。
■回顾性分析从MD患者和健康对照（HC）获得的各向同性U-HRCT图像。我们提取了半规管结构并提取了它们的骨架。每个半规管的骨架平面分别安装。半圆形运河之间的相互角度，并测量了每个半规管与坐标系每个平面之间的角度。
■在45只受MD影响的耳朵（MDAE）中，33只MD健康的耳朵（MDHE），和45只HC耳朵，MDAE和MDHE组的上半规管与外侧半规管（LSCs）之间的角度和上半规管与后半规管（PSC）之间的角度均大于HC组（P<0.01），MDAE组后端与LSCs之间的夹角小于HC组（P<0.001）。MDAE组和MDHE组的上、PSC与坐标系冠状面(CP)的夹角明显小于HC组(P<0.01);MDAE和MDHE组的LSC与轴向平面和CP之间的角度明显大于HC组（P<0.001）。
■半规管的空间位置变化可能是MD的解剖学基础。
