PDF(Pubmed)
Abstract：
Neutrophils are recognized active participants in inflammatory responses and are intricately linked to cancer progression. In response to inflammatory stimuli, neutrophils become activated, releasing neutrophils extracellular traps (NETs) for the capture and eradication of pathogens, a phenomenon termed NETosis. With a deeper understanding of NETs, there is growing evidence supporting their role in cancer progression and their involvement in conferring resistance to various cancer therapies, especially concerning tumor reactions to chemotherapy, radiation therapy (RT), and immunotherapy. This review summarizes the roles of NETs in the tumor microenvironment (TME) and their mechanisms of neutrophil involvement in the host defense. Additionally, it elucidates the mechanisms through which NETs promote tumor progression and their role in cancer treatment resistance, highlighting their potential as promising therapeutic targets in cancer treatment and their clinical applicability.
摘要：
中性粒细胞被认为是炎症反应的积极参与者，并且与癌症进展密切相关。作为对炎症刺激的反应，中性粒细胞被激活，释放嗜中性粒细胞胞外陷阱（NETs）用于捕获和根除病原体，一种被称为NETosis的现象。随着对NET的深入了解,越来越多的证据支持它们在癌症进展中的作用，以及它们参与赋予对各种癌症疗法的抗性，尤其是肿瘤对化疗的反应，放射治疗（RT），和免疫疗法。本文综述了NETs在肿瘤微环境(TME)中的作用及其参与宿主防御的机制。此外,它阐明了NET促进肿瘤进展的机制及其在癌症治疗抵抗中的作用，强调它们作为癌症治疗中的有希望的治疗靶点的潜力及其临床适用性。
