Abstract：
Fluorinated liquid-crystal monomers (FLCMs) are a potential emerging class of persistent, bioaccumulative, and toxic compounds. Humans inevitably ingest FLCMs via food and the environment. However, there are limited studies on internal exposure biomonitoring of FLCMs. Herein, we evaluated the estimated daily intakes (EDIs) of FLCMs in the general population based on serum residue levels. For the first time, 38 FLCMs were detected in 314 serum samples from the general population in Beijing, with a median value of 132.48 ng/g of lipid weight (lw). BDPrB is a predominant FLCM in serum. The median EDI of ∑38FLCMs in the general residents was 37.96 pg/kg bw/day. The residual levels of most FLCMs were higher in urban than in suburban areas (p < 0.05). The concentrations of EFPEB, EDPrB, EDFPBB, and PDTFMTFT in serum showed positive associations with blood glucose (GLU) (r = 0.126-0.275, p < 0.05). Logistic regression analysis showed that FLCMs were significantly positively correlated with dyslipidemia, with an odds ratio of 2.19; BDPrB was significantly positively correlated with hyperglycemia (OR: 2.48). Overall, the present study suggests the occurrence of FLCMs in the nonoccupational population, and the exposure of certain FLCMs may cause abnormal blood glucose and lipid levels.
摘要：
氟化液晶单体(FLCM)是一类潜在的新兴的持久性，生物蓄积性，和有毒化合物。人类不可避免地通过食物和环境摄入FLCM。然而,关于FLCM内部暴露生物监测的研究有限。在此，我们根据血清残留水平评估了普通人群中FLCM的估计日摄入量(EDI).第一次,在北京普通人群的314份血清样本中检测到38份FLCM，中位值为132.48ng/g脂质重量（lw）。BDPrB是血清中的主要FLCM。一般居民∑38FLCM的EDI中位数为37.96pg/kgbw/天。城市地区大多数FLCM的残留水平高于郊区（p<0.05）。EFPEB的浓度，EDPrB,EDFPBB,血清中PDTFMTFT与血糖（GLU）呈正相关（r=0.126-0.275，p<0.05）。Logistic回归分析显示,FLCMs与血脂异常呈显著正相关,比值比为2.19;BDPrB与高血糖呈显著正相关(OR:2.48)。总的来说,本研究表明，FLCM在非职业人群中的发生，某些FLCM的暴露可能会导致血糖和血脂水平异常。
