Abstract：
UNASSIGNED: To explore the expression of matrix metalloproteinase-3 (MMP-3) in the aqueous humor of patients with Posner-Schlossman syndrome (PSS), and the association between MMP-3 and PSS.
UNASSIGNED: Peripheral blood and aqueous humor were routinely collected from 29 patients with PSS (PSS group) and 30 patients with age-related-cataract (ARC) (control group). The content of MMP-3 in serum and aqueous humor was measured by immunoturbidimetry. The correlation between MMP-3 and ophthalmic examination results were verified by Spearman\'s correlation analysis.
UNASSIGNED: The MMP-3 level in the aqueous humor of the PSS group was (25.86 ± 13.4)ng/ml, significantly higher than that in the control group (3.9 ± 2.7)ng/ml(p < 0.001), while there was no significant difference in serum MMP-3 level between the two groups (p = 0.125). The endothelial cell density (ECD) in the aqueous humor of the PSS group was (2078 ± 440) cell/mm2, intraocular pressure (IOP) in the aqueous humor of the PSS group was (33 ± 12) mmHg. The correlation analysis of aqueous humor MMP-3 and various ophthalmic examination results showed that aqueous humor MMP-3 had a moderate correlation with IOP and the difference in ECD between the affected eye and the fellow eye.
UNASSIGNED: MMP-3 level is elevated in the aqueous humor of PSS patients, and it may play an important role in the pathogenesis of PSS.
UNASSIGNED: Peripheral blood and aqueous humor were routinely collected from 29 patients with PSS (PSS group) and 30 patients with age-related-cataract (ARC) (control group). The content of MMP-3 in serum and aqueous humor was measured by immunoturbidimetry. The correlation between MMP-3 and ophthalmic examination results were verified by Spearman\'s correlation analysis.
UNASSIGNED: The MMP-3 level in the aqueous humor of the PSS group was (25.86 ± 13.4)ng/ml, significantly higher than that in the control group (3.9 ± 2.7)ng/ml(p < 0.001), while there was no significant difference in serum MMP-3 level between the two groups (p = 0.125). The endothelial cell density (ECD) in the aqueous humor of the PSS group was (2078 ± 440) cell/mm2, intraocular pressure (IOP) in the aqueous humor of the PSS group was (33 ± 12) mmHg. The correlation analysis of aqueous humor MMP-3 and various ophthalmic examination results showed that aqueous humor MMP-3 had a moderate correlation with IOP and the difference in ECD between the affected eye and the fellow eye.
UNASSIGNED: MMP-3 level is elevated in the aqueous humor of PSS patients, and it may play an important role in the pathogenesis of PSS.
摘要：
■探讨基质金属蛋白酶-3（MMP-3）在Posner-Schlossman综合征（PSS）患者房水中的表达，以及MMP-3与PSS之间的关系。
■常规采集29例PSS患者（PSS组）和30例年龄相关性白内障（ARC）患者（对照组）的外周血和房水。免疫比浊法检测血清和房水中MMP-3的含量。通过Spearman相关分析验证MMP-3与眼科检查结果的相关性。
■PSS组房水MMP-3水平为（25.86±13.4）ng/ml，显著高于对照组(3.9±2.7)ng/ml(p<0.001),而血清MMP-3水平在两组之间没有显着差异（p=0.125）。PSS组房水内皮细胞密度(ECD)为(2078±440)个细胞/mm2,PSS组房水眼压(IOP)为(33±12)mmHg。房水MMP-3与各种眼科检查结果的相关性分析表明，房水MMP-3与患眼和同眼之间的IOP和ECD差异具有中度相关性。
■PSS患者房水MMP-3水平升高，可能在PSS的发病机制中起重要作用。
■常规采集29例PSS患者（PSS组）和30例年龄相关性白内障（ARC）患者（对照组）的外周血和房水。免疫比浊法检测血清和房水中MMP-3的含量。通过Spearman相关分析验证MMP-3与眼科检查结果的相关性。
■PSS组房水MMP-3水平为（25.86±13.4）ng/ml，显著高于对照组(3.9±2.7)ng/ml(p<0.001),而血清MMP-3水平在两组之间没有显着差异（p=0.125）。PSS组房水内皮细胞密度(ECD)为(2078±440)个细胞/mm2,PSS组房水眼压(IOP)为(33±12)mmHg。房水MMP-3与各种眼科检查结果的相关性分析表明，房水MMP-3与患眼和同眼之间的IOP和ECD差异具有中度相关性。
■PSS患者房水MMP-3水平升高，可能在PSS的发病机制中起重要作用。
