METHODS: Twenty-nine patients with type 2 diabetes were enrolled and hospitalized to receive a 2-week intensive glycaemic control regimen. We observed and analysed the systemic and oral disease indicators before and after treatment and clarified the indicators related to periodontal inflammation.
RESULTS: A significant reduction in glycaemic and periodontal parameters, including glycated albumin levels and periodontal inflamed surface area (PISA), was observed after treatment. The changes in PISA per tooth, indicative of periodontal healing, exhibited a bimodal distribution; the patients were divided into two groups on this basis. Correlations were observed between the changes in PISA per tooth and fasting plasma glucose, acetoacetic acid, and beta-hydroxybutyrate levels in the PISA-improved group. Significantly lower levels of C-peptide, coefficient of variation of R-R interval, and ankle-brachial pressure index were observed before treatment in the PISA non-improved group.
CONCLUSIONS: Glycaemic control treatment can effectively improve periodontitis in patients with type 2 diabetes, even in the absence of specific periodontal treatments. However, the periodontal responsiveness to glycaemic control treatment depends on the systemic condition of the patient.
方法:29例2型糖尿病患者被纳入并住院接受为期2周的强化血糖控制方案。观察并分析治疗前后全身及口腔疾病指标,明确与牙周炎症相关的指标。
结果:血糖和牙周参数显着降低,包括糖化白蛋白水平和牙周发炎表面积(PISA),治疗后观察。每颗牙齿的PISA变化,指示牙周愈合,表现出双峰分布;在此基础上将患者分为两组。观察到每颗牙齿的PISA变化与空腹血糖之间的相关性。乙酰乙酸,和β-羟丁酸水平在PISA改善组。显著降低C肽水平,R-R区间的变异系数,PISA未改善组治疗前观察踝臂压指数。
结论:血糖控制治疗能有效改善2型糖尿病患者的牙周炎,即使没有特定的牙周治疗。然而,牙周对血糖控制治疗的反应性取决于患者的全身状况。