METHODS: We enrolled 118 consecutive current smokers without previous coronary artery disease (72.9% were men; age: 59 ± 11 years) who underwent smoking cessation treatment. The clinical variables %FMD, %L-FMC, and %FMTD were examined before and 20 weeks after treatment initiation. A multivariate linear regression model was used to investigate the effects of smoking cessation on %FMD and %FMTD and the interaction between smoking cessation and baseline clinical variables.
RESULTS: After 20 weeks, 85 smokers (69.4% were men; age: 59 ± 12 years) ceased smoking (abstainers), whereas 33 smokers (81.8% were men; age: 58 ± 11 years) did not (continued smokers). The estimated group differences (abstainers - continued smokers) in changes in the %FMD and %FMTD were 0.77% (95% confidence interval [CI], -0.22-1.77%; p = 0.129) and 1.17% (95% CI, 0.16-2.18%; p = 0.024), respectively. Smoking cessation-associated improvement in %FMTD was greater in women than in men (5.41% [95% CI, 3.15-7.67%] versus 0.24% [95% CI, -0.81-1.28%]; p-value for interaction, < 0.001). Additionally, a greater %FMTD improvement was observed in patients who smoked fewer cigarettes per day (p-value for interaction, 0.042) and those who had a smaller resting baseline lumen diameter (Dbase) (p-value for interaction, 0.023).
CONCLUSIONS: Smoking cessation was associated with an improvement in %FMTD. Sex, cigarettes smoked per day, and Dbase significantly affected this improvement. The FMTD may help in risk stratification after smoking cessation.
方法:我们招募了118名连续吸烟者,这些吸烟者没有既往冠状动脉疾病(72.9%为男性;年龄:59±11岁),他们接受了戒烟治疗。临床变量%FMD,%L-FMC,在治疗开始前和治疗后20周检查%FMTD。使用多元线性回归模型来研究戒烟对%FMD和%FMTD的影响以及戒烟与基线临床变量之间的相互作用。
结果:20周后,85名吸烟者(69.4%为男性;年龄:59±12岁)停止吸烟(戒酒者),而33名吸烟者(81.8%为男性;年龄:58±11岁)没有(持续吸烟者)。%FMD和%FMTD变化的估计组差异(戒烟者-持续吸烟者)为0.77%(95%置信区间[CI],-0.22-1.77%;p=0.129)和1.17%(95%CI,0.16-2.18%;p=0.024),分别。与戒烟相关的%FMTD改善在女性中大于男性(5.41%[95%CI,3.15-7.67%]vs.0.24%[95%CI,-0.81-1.28%];p值用于互动,<0.001)。此外,在每天吸烟较少的患者中观察到更大的%FMTD改善(相互作用的p值,0.042)和那些具有较小的静息基线管腔直径(Dbase)(相互作用的p值,0.023).
结论:戒烟与%FMTD的改善相关。性,每天吸烟,和Dbase显著影响了这一改进。FMTD可能有助于戒烟后的风险分层。