PDF(Pubmed)
Abstract：
Chronic kidney disease (CKD) is a heterogeneous disorder that affects the kidney structure and function. This study investigated the effect of the interaction between genetic factors and dietary pattern on kidney dysfunction in Korean adults.
Baseline data were obtained from the Ansan and Ansung Study of the Korean Genome and Epidemiology Study involving 8230 participants aged 40-69 years. Kidney dysfunction was defined as an estimated glomerular filtration rate < 90 mL/minute/1.73 m2. Genomic DNAs genotyped on the Affymetrix® Genome-Wide Human SNP array 5.0 were isolated from peripheral blood. A genome-wide association study using a generalized linear model was performed on 1,590,162 single-nucleotide polymorphisms (SNPs). To select significant SNPs, the threshold criterion was set at P-value < 5 × 10-8. Linkage disequilibrium clumping was performed based on the R2 value, and 94 SNPs had a significant effect. Participants were divided into two groups based on their generic risk score (GRS): the low-GR group had GRS > 0, while the high-GR group had GRS ≤ 0.
Three distinct dietary patterns were extracted, namely, the \"prudent pattern,\" \"flour-based and animal food pattern,\" and \"white rice pattern,\" to analyze the effect of dietary pattern on kidney function. In the \"flour-based and animal food pattern,\" higher pattern scores were associated with a higher prevalence of kidney dysfunction in both the low and high GR groups (P for trend < 0.0001 in the low-, high-GR groups of model 1; 0.0050 and 0.0065 in the low-, high-GR groups of model 2, respectively).
The results highlight a significant association between the \'flour-based and animal food pattern\' and higher kidney dysfunction prevalence in individuals with both low and high GR. These findings suggest that personalized nutritional interventions based on GR profiles may become the basis for presenting GR-based individual dietary patterns for kidney dysfunction.
Baseline data were obtained from the Ansan and Ansung Study of the Korean Genome and Epidemiology Study involving 8230 participants aged 40-69 years. Kidney dysfunction was defined as an estimated glomerular filtration rate < 90 mL/minute/1.73 m2. Genomic DNAs genotyped on the Affymetrix® Genome-Wide Human SNP array 5.0 were isolated from peripheral blood. A genome-wide association study using a generalized linear model was performed on 1,590,162 single-nucleotide polymorphisms (SNPs). To select significant SNPs, the threshold criterion was set at P-value < 5 × 10-8. Linkage disequilibrium clumping was performed based on the R2 value, and 94 SNPs had a significant effect. Participants were divided into two groups based on their generic risk score (GRS): the low-GR group had GRS > 0, while the high-GR group had GRS ≤ 0.
Three distinct dietary patterns were extracted, namely, the \"prudent pattern,\" \"flour-based and animal food pattern,\" and \"white rice pattern,\" to analyze the effect of dietary pattern on kidney function. In the \"flour-based and animal food pattern,\" higher pattern scores were associated with a higher prevalence of kidney dysfunction in both the low and high GR groups (P for trend < 0.0001 in the low-, high-GR groups of model 1; 0.0050 and 0.0065 in the low-, high-GR groups of model 2, respectively).
The results highlight a significant association between the \'flour-based and animal food pattern\' and higher kidney dysfunction prevalence in individuals with both low and high GR. These findings suggest that personalized nutritional interventions based on GR profiles may become the basis for presenting GR-based individual dietary patterns for kidney dysfunction.
摘要：
慢性肾脏病（CKD）是一种影响肾脏结构和功能的异质性疾病。这项研究调查了遗传因素和饮食模式之间的相互作用对韩国成年人肾功能障碍的影响。
基线数据来自韩国基因组和流行病学研究的Ansan和Ansung研究，涉及8230名40-69岁的参与者。肾功能障碍定义为估计的肾小球滤过率<90mL/分钟/1.73m2。从外周血中分离在Affymetrix®全基因组人类SNP阵列5.0上进行基因分型的基因组DNA。使用广义线性模型对1,590,162个单核苷酸多态性（SNP）进行了全基因组关联研究。要选择重要的SNP，阈值标准设定为P值<5×10-8。基于R2值进行连锁不平衡聚集，94个SNPs具有显著的效应。根据一般风险评分（GRS）将参与者分为两组：低GR组的GRS>0，而高GR组的GRS≤0。
提取了三种不同的饮食模式，即,“谨慎的模式，“\”面粉和动物性食品模式，“和”白米图案，分析膳食模式对肾功能的影响。在“以面粉和动物性食品为主的模式中，在低GR组和高GR组中，较高的模式评分与较高的肾功能障碍患病率相关(低GR组的趋势P<0.0001,模型1的高GR组；低GR组的0.0050和0.0065，分别为模型2的高GR组)。
结果突出表明，在低和高GR的个体中，“以面粉为基础的食物模式和动物食物模式”与更高的肾功能障碍患病率之间存在显着关联。这些发现表明，基于GR概况的个性化营养干预可能成为提出基于GR的个体饮食模式治疗肾功能障碍的基础。
基线数据来自韩国基因组和流行病学研究的Ansan和Ansung研究，涉及8230名40-69岁的参与者。肾功能障碍定义为估计的肾小球滤过率<90mL/分钟/1.73m2。从外周血中分离在Affymetrix®全基因组人类SNP阵列5.0上进行基因分型的基因组DNA。使用广义线性模型对1,590,162个单核苷酸多态性（SNP）进行了全基因组关联研究。要选择重要的SNP，阈值标准设定为P值<5×10-8。基于R2值进行连锁不平衡聚集，94个SNPs具有显著的效应。根据一般风险评分（GRS）将参与者分为两组：低GR组的GRS>0，而高GR组的GRS≤0。
提取了三种不同的饮食模式，即,“谨慎的模式，“\”面粉和动物性食品模式，“和”白米图案，分析膳食模式对肾功能的影响。在“以面粉和动物性食品为主的模式中，在低GR组和高GR组中，较高的模式评分与较高的肾功能障碍患病率相关(低GR组的趋势P<0.0001,模型1的高GR组；低GR组的0.0050和0.0065，分别为模型2的高GR组)。
结果突出表明，在低和高GR的个体中，“以面粉为基础的食物模式和动物食物模式”与更高的肾功能障碍患病率之间存在显着关联。这些发现表明，基于GR概况的个性化营养干预可能成为提出基于GR的个体饮食模式治疗肾功能障碍的基础。
