Abstract：
BACKGROUND: The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants?
METHODS: We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N = 4,255-6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.
RESULTS: Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences.
CONCLUSIONS: These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.
METHODS: We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N = 4,255-6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.
RESULTS: Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences.
CONCLUSIONS: These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.
摘要：
背景：已知自闭症和注意力缺陷多动障碍（ADHD）特征的遗传和环境病因在空间上有所不同，但是这是否转化为特定常见遗传变异的关联变化？
方法：我们在布里斯托尔周边地区的雅芳父母和儿童纵向研究（N=4,255-6,165）中绘制了自闭症和多动症的多基因评分与其各自特征之间的关联图，英国,并将它们与自闭症和多动症患病率相关的环境图进行比较。
结果：我们的结果表明遗传关联在空间上有所不同，在不同p值阈值下构建的多基因评分中，自闭症特征的模式一致。多动症性状的模式在不同阈值之间的差异更大。我们发现空间分布通常与已知的环境影响相关。
结论：这些发现揭示了导致自闭症和多动症特征中环境与遗传影响之间复杂相互作用的因素。
方法：我们在布里斯托尔周边地区的雅芳父母和儿童纵向研究（N=4,255-6,165）中绘制了自闭症和多动症的多基因评分与其各自特征之间的关联图，英国,并将它们与自闭症和多动症患病率相关的环境图进行比较。
结果：我们的结果表明遗传关联在空间上有所不同，在不同p值阈值下构建的多基因评分中，自闭症特征的模式一致。多动症性状的模式在不同阈值之间的差异更大。我们发现空间分布通常与已知的环境影响相关。
结论：这些发现揭示了导致自闭症和多动症特征中环境与遗传影响之间复杂相互作用的因素。
