Abstract：
BACKGROUND: Cardiac T1 mapping is valuable for evaluating myocardial fibrosis, yet its resolution and acquisition efficiency are limited, potentially obscuring visualization of small pathologies.
OBJECTIVE: To develop a technique for high-resolution cardiac T1 mapping with a less-than-100-millisecond acquisition window based on radial MOdified Look-Locker Inversion recovery (MOLLI) and a calibrationless space-contrast-coil locally low-rank tensor (SCC-LLRT) constrained reconstruction.
METHODS: Prospective.
METHODS: Sixteen healthy subjects (age 25 ± 3 years, 44% females) and 12 patients with suspected cardiomyopathy (age 57 ± 15 years, 42% females), NiCl2-agar phantom.
UNASSIGNED: 3-T, standard MOLLI, radial MOLLI, inversion-recovery spin-echo, late gadolinium enhancement.
RESULTS: SCC-LLRT was compared to a conventional locally low-rank (LLR) method through simulations using Normalized Root-Mean-Square Error (NRMSE) and Structural Similarity Index Measure (SSIM). Radial MOLLI was compared to standard MOLLI across phantom, healthy subjects, and patients. Three independent readers subjectively evaluated the quality of T1 maps using a 5-point scale (5 = best).
METHODS: Paired t-test, Wilcoxon signed-rank test, intraclass correlation coefficient analysis, linear regression, Bland-Altman analysis. P < 0.05 was considered statistically significant.
RESULTS: In simulations, SCC-LLRT demonstrated a significant improvement in NRMSE and SSIM compared to LLR. In phantom, both radial MOLLI and standard MOLLI provided consistent T1 estimates across different heart rates. In healthy subjects, radial MOLLI exhibited a significantly lower mean T1 (1115 ± 39 msec vs. 1155 ± 36 msec), similar T1 SD (74 ± 14 msec vs. 67 ± 23 msec, P = 0.20), and similar T1 reproducibility (28 ± 18 msec vs. 22 ± 15 msec, P = 0.34) compared to standard MOLLI. In patients, the proposed method significantly improved the sharpness of myocardial boundaries (4.50 ± 0.65 vs. 3.25 ± 0.43), the conspicuity of papillary muscles and fine structures (4.33 ± 0.74 vs. 3.33 ± 0.47), and artifacts (4.75 ± 0.43 vs. 3.83 ± 0.55). The reconstruction time for a single slice was 5.2 hours.
CONCLUSIONS: The proposed method enables high-resolution cardiac T1 mapping with a short acquisition window and improved image quality.
METHODS: 1 TECHNICAL EFFICACY: Stage 1.
OBJECTIVE: To develop a technique for high-resolution cardiac T1 mapping with a less-than-100-millisecond acquisition window based on radial MOdified Look-Locker Inversion recovery (MOLLI) and a calibrationless space-contrast-coil locally low-rank tensor (SCC-LLRT) constrained reconstruction.
METHODS: Prospective.
METHODS: Sixteen healthy subjects (age 25 ± 3 years, 44% females) and 12 patients with suspected cardiomyopathy (age 57 ± 15 years, 42% females), NiCl2-agar phantom.
UNASSIGNED: 3-T, standard MOLLI, radial MOLLI, inversion-recovery spin-echo, late gadolinium enhancement.
RESULTS: SCC-LLRT was compared to a conventional locally low-rank (LLR) method through simulations using Normalized Root-Mean-Square Error (NRMSE) and Structural Similarity Index Measure (SSIM). Radial MOLLI was compared to standard MOLLI across phantom, healthy subjects, and patients. Three independent readers subjectively evaluated the quality of T1 maps using a 5-point scale (5 = best).
METHODS: Paired t-test, Wilcoxon signed-rank test, intraclass correlation coefficient analysis, linear regression, Bland-Altman analysis. P < 0.05 was considered statistically significant.
RESULTS: In simulations, SCC-LLRT demonstrated a significant improvement in NRMSE and SSIM compared to LLR. In phantom, both radial MOLLI and standard MOLLI provided consistent T1 estimates across different heart rates. In healthy subjects, radial MOLLI exhibited a significantly lower mean T1 (1115 ± 39 msec vs. 1155 ± 36 msec), similar T1 SD (74 ± 14 msec vs. 67 ± 23 msec, P = 0.20), and similar T1 reproducibility (28 ± 18 msec vs. 22 ± 15 msec, P = 0.34) compared to standard MOLLI. In patients, the proposed method significantly improved the sharpness of myocardial boundaries (4.50 ± 0.65 vs. 3.25 ± 0.43), the conspicuity of papillary muscles and fine structures (4.33 ± 0.74 vs. 3.33 ± 0.47), and artifacts (4.75 ± 0.43 vs. 3.83 ± 0.55). The reconstruction time for a single slice was 5.2 hours.
CONCLUSIONS: The proposed method enables high-resolution cardiac T1 mapping with a short acquisition window and improved image quality.
METHODS: 1 TECHNICAL EFFICACY: Stage 1.
摘要：
背景：心脏T1标测对于评估心肌纤维化很有价值，然而它的分辨率和获取效率是有限的，潜在模糊的小病理的可视化。
目的：开发一种基于径向MOdifiedLook-LockerInversionrecovery(MOLLI)和无校准空间对比线圈局部低秩张量(SCC-LLRT)约束重建的高分辨率心脏T1标测技术。
方法：前瞻性。
方法：16名健康受试者（年龄25±3岁，44％女性）和12例疑似心肌病患者（年龄57±15岁，42％的女性），NiCl2-琼脂幻影。
■3-T,标准MOLLI,径向莫利,反转恢复自旋回波，晚钆增强。
结果：通过使用归一化均方根误差（NRMSE）和结构相似性指数度量（SSIM）的模拟，将SCC-LLRT与传统的局部低秩（LLR）方法进行了比较。通过体模将径向MOLLI与标准MOLLI进行比较，健康的受试者,和病人。三个独立的读者使用5点比例（5=最佳）主观评估了T1图的质量。
方法：配对t检验，Wilcoxon符号秩检验,组内相关系数分析，线性回归，Bland-Altman分析P<0.05被认为具有统计学意义。
结果：在模拟中，与LLR相比，SCC-LLRT在NRMSE和SSIM中表现出显着改善。在幻影中，径向MOLLI和标准MOLLI在不同心率下提供一致的T1估计值.在健康的受试者中，径向MOLLI表现出明显较低的平均T1(1115±39毫秒与1155±36毫秒),相似的T1SD（74±14毫秒与67±23毫秒，P=0.20),和相似的T1再现性(28±18毫秒与22±15毫秒，P=0.34）与标准MOLLI相比。在患者中，所提出的方法显着提高了心肌边界的清晰度（4.50±0.65vs.3.25±0.43)，乳头状肌和精细结构的显着性(4.33±0.74vs.3.33±0.47)，和伪影(4.75±0.43vs.3.83±0.55)。单个切片的重建时间为5.2小时。
结论：所提出的方法能够实现具有短采集窗口和改善的图像质量的高分辨率心脏T1标测。
方法：1技术效果：第一阶段。
目的：开发一种基于径向MOdifiedLook-LockerInversionrecovery(MOLLI)和无校准空间对比线圈局部低秩张量(SCC-LLRT)约束重建的高分辨率心脏T1标测技术。
方法：前瞻性。
方法：16名健康受试者（年龄25±3岁，44％女性）和12例疑似心肌病患者（年龄57±15岁，42％的女性），NiCl2-琼脂幻影。
■3-T,标准MOLLI,径向莫利,反转恢复自旋回波，晚钆增强。
结果：通过使用归一化均方根误差（NRMSE）和结构相似性指数度量（SSIM）的模拟，将SCC-LLRT与传统的局部低秩（LLR）方法进行了比较。通过体模将径向MOLLI与标准MOLLI进行比较，健康的受试者,和病人。三个独立的读者使用5点比例（5=最佳）主观评估了T1图的质量。
方法：配对t检验，Wilcoxon符号秩检验,组内相关系数分析，线性回归，Bland-Altman分析P<0.05被认为具有统计学意义。
结果：在模拟中，与LLR相比，SCC-LLRT在NRMSE和SSIM中表现出显着改善。在幻影中，径向MOLLI和标准MOLLI在不同心率下提供一致的T1估计值.在健康的受试者中，径向MOLLI表现出明显较低的平均T1(1115±39毫秒与1155±36毫秒),相似的T1SD（74±14毫秒与67±23毫秒，P=0.20),和相似的T1再现性(28±18毫秒与22±15毫秒，P=0.34）与标准MOLLI相比。在患者中，所提出的方法显着提高了心肌边界的清晰度（4.50±0.65vs.3.25±0.43)，乳头状肌和精细结构的显着性(4.33±0.74vs.3.33±0.47)，和伪影(4.75±0.43vs.3.83±0.55)。单个切片的重建时间为5.2小时。
结论：所提出的方法能够实现具有短采集窗口和改善的图像质量的高分辨率心脏T1标测。
方法：1技术效果：第一阶段。
