METHODS: Retrospective, clinical, cohort study.
METHODS: A group of 73 client-owned horses treated with salbutamol when PaO2 <100 mmHg (13.3 kPa) during anaesthesia.
METHODS: Horses were divided into two groups: responders (R), where PaO2 after salbutamol ≥1.2 PaO2 before treatment (i.e. ≥20% increase), and non-responders (NR), where PaO2 after salbutamol <1.2 PaO2 before treatment. Demographic data and intraoperative variables before treatment were compared between R and NR. Cdyn, arterial to end-tidal carbon dioxide difference [P(a-E´)CO2], estimated ratio of dead space to tidal volume (est.VD/VT), estimated shunt fraction (F-shunt), heart rate, systolic, mean and diastolic arterial pressure and dobutamine requirements were compared before and after treatment within R and NR. For each variable, the difference (Δ) between values pre- and posttreatment was calculated and compared between groups R and NR. Numerical data were compared using univariate or bivariate analysis and categorical data were compared using chi-square test; p < 0.05.
RESULTS: Of the 73 horses 50 were classified as R while 23 horses were classified as NR. There was no statistical difference between R and NR for demographic data or initial intraoperative variables except for body weight [R: 531 (170-715) kg, NR: 540 (420-914) kg]. While salbutamol did not alter Cdyn in either group, it significantly decreased P(a-E´)CO2, est.VD/VT and F-shunt in R only. ΔP(a-E´)CO2, Δest.VD/VT and ΔF-shunt were significantly greater in R (-17.8%, -19.0% and -24.1%, respectively) than in NR (11.5%, 6.6% and -0.3%, respectively).
CONCLUSIONS: In hypoxaemic anaesthetized horses responding to inhaled salbutamol by a ≥1.2 increase in PaO2 no change in Cdyn was detected, but indicators of V˙/ Q˙ mismatch improved.
方法:回顾性,临床,队列研究。
方法:在麻醉期间,当PaO2<100mmHg(13.3kPa)时,使用沙丁胺醇治疗的73匹客户拥有的马。
方法:将马分为两组:反应者(R),其中沙丁胺醇后的PaO2≥1.2治疗前的PaO2(即≥20%的增加),和非响应者(NR),其中沙丁胺醇后的PaO2<1.2治疗前的PaO2。比较R和NR治疗前的人口统计学数据和术中变量。Cdyn,动脉与呼气末二氧化碳差[P(a-E')CO2],估计死区与潮气量之比(估计。VD/VT),估计分流分数(F分流),心率,收缩压,在R和NR治疗前后比较平均和舒张压和多巴酚丁胺需求。对于每个变量,计算治疗前后值之间的差异(Δ),并比较R组和NR组之间的差异。使用单变量或双变量分析比较数值数据,使用卡方检验比较分类数据;p<0.05。
结果:在73匹马中,有50匹马被归类为R,而有23匹马被归类为NR。除了体重[R:531(170-715)kg,R和NR之间的人口统计学数据或术中初始变量没有统计学差异,NR:540(420-914)kg]。虽然沙丁胺醇在任何一组中都没有改变Cdyn,它显着降低了P(a-E')CO2。仅R中的VD/VT和F分流。ΔP(a-E')CO2,Δest。VD/VT和ΔF分流在R中显著更大(-17.8%,-19.0%和-24.1%,分别)比NR(11.5%,6.6%和-0.3%,分别)。
结论:在低氧麻醉马中,对吸入沙丁胺醇的PaO2增加≥1.2的反应没有检测到Cdyn的变化,但是V*/Q*不匹配的指标有所改善。