关键词: Anabolic Bone Agents Bisphosphonates Fracture Prevention Osteoporosis

Mesh : Humans Bone Density Conservation Agents / therapeutic use Osteoporosis / drug therapy Female Antibodies, Monoclonal / therapeutic use Osteoporotic Fractures / prevention & control etiology Parathyroid Hormone-Related Protein Teriparatide / therapeutic use Diphosphonates / therapeutic use

来  源:   DOI:10.3122/jabfm.2024.240060R0

Abstract:
Anabolic bone agents, such as parathyroid hormone receptor agonists (teriparatide and abaloparatide) and sclerostin-inhibiting monoclonal antibody (romosozumab), are superior at preventing clinically significant fractures and/or vertebral fractures in women with and without severe osteoporosis compared with bisphosphonates.
摘要:
合成代谢骨剂,如甲状旁腺激素受体激动剂(特立帕肽和阿巴罗帕拉肽)和硬化素抑制单克隆抗体(romosozumab),与双膦酸盐相比,有和没有严重骨质疏松症的女性在预防临床上明显的骨折和/或椎骨骨折方面具有优势。
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