Abstract：
Presented are three casuistics of seemingly identical breast lesions which even by adopting advanced laboratory techniques may represent diagnostic challenge. Microscopic features of some bland spindle cell lesions of different histogenesis (epithelial or mesenchymal) are misleading and a potential source of unaware errors, which might affect optimal therapeutic strategy. In the setting of three diverse entities (low-grade spindle cell metaplastic carcinoma, desmoid fibromatosis and phyllodes tumor) is documented both demanding diagnostic algorithm and revealing molecular landscape on one side as well as evolving predictive/prognostic parameters on the other one. Close interdisciplinary cooperation is inevitable for accurate interpretation/understanding of revealed diagnostic facts which is required for adjustment of competent rational and individualized therapy.
摘要：
提出了三种看似相同的乳腺病变的证据，即使采用先进的实验室技术也可能代表诊断挑战。一些不同组织发生的平淡梭形细胞病变（上皮或间充质）的显微镜特征具有误导性，并且是未知错误的潜在来源。这可能会影响最佳治疗策略。在三个不同实体的背景下（低级梭形细胞化生性癌，纤维瘤样纤维瘤病和叶状肿瘤）一方面需要诊断算法，一方面揭示分子景观，另一方面也在不断发展预测/预后参数。密切的跨学科合作对于准确解释/理解揭示的诊断事实是不可避免的，这对于调整合格的理性和个性化治疗是必需的。
