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Abstract：
Using 1998-2022 Women\'s Health Initiative (WHI) data, our study provides contemporary fracture data by race and ethnicity, specifically focusing on Hispanic and Asian women. Fractures of interest included any clinical, hip, and major osteoporotic fractures (MOFs). We utilized the updated race and ethnicity information collected in 2003, which included seven Asian and five Hispanic origin groups. We computed crude and age-standardized fracture incidence rates per 10 000 woman-years across race and ethnic categories and by Asian and Hispanic origin. We used Cox proportional hazards model, adjusting for age and WHI clinical trial arm, to evaluate the risk of fracture (1) by race compared to White women, (2) Asian origin compared to White women, (3) Hispanic compared to non-Hispanic women, and (4) Asian and Hispanic origins compared the most prevalent origin group. Over a median (interquartile range) follow-up of 19.4 (9.2-24.2) years, 44.2% of the 160 824 women experienced any clinical fracture, including 36 278 MOFs and 8962 hip fractures. Compared to White women, Black, Pacific Islander, Asian, and multiracial women had significantly lower risk of any clinical and MOFs, while only Black and Asian women had significantly lower hip fracture risk. Within Asian women, Filipina women had 24% lower risk of any clinical fracture compared to Japanese women. Hispanic women had significantly lower risk of any clinical, hip, and MOF fractures compared to non-Hispanic women, with no differences in fracture risk observed within Hispanic origin groups. In this diverse sample of postmenopausal women, we confirmed racial and ethnic differences in fracture rates and risk, with novel findings among within Asian and Hispanic subgroups. These data can aid in future longitudinal studies evaluate contributors to racial and ethnic differences in fractures.
We provided contemporary fracture rates by race and ethnicity, specifically focusing on multiple Hispanic and Asian subgroups, using 1998-2022 data from the Women’s Health Initiative. Over a median follow-up of 19.4 years, 43.4% of the 154 948 women experienced any clinical fracture, including 8679 hip and 34 546 major osteoporotic fractures. Compared to White women, Black, Pacific Islander, Asian, and multiracial women had significantly lower risk of any clinical and major osteoporotic fractures (MOFs); while only Black and Asian women had significantly lower hip fracture risk when compared to White women. Within Asian women, Filipina women had 24% lower risk of any clinical fracture compared to Japanese women. Hispanic women had significantly lower risk of any clinical, hip, and MOF fractures compared to non-Hispanic women, with no differences in fracture risk observed within Hispanic women. In this diverse sample of postmenopausal women, we confirmed racial and ethnic differences in fracture rates and risk, with novel findings among Pacific Islander women and within Asian and Hispanic subgroups.
We provided contemporary fracture rates by race and ethnicity, specifically focusing on multiple Hispanic and Asian subgroups, using 1998-2022 data from the Women’s Health Initiative. Over a median follow-up of 19.4 years, 43.4% of the 154 948 women experienced any clinical fracture, including 8679 hip and 34 546 major osteoporotic fractures. Compared to White women, Black, Pacific Islander, Asian, and multiracial women had significantly lower risk of any clinical and major osteoporotic fractures (MOFs); while only Black and Asian women had significantly lower hip fracture risk when compared to White women. Within Asian women, Filipina women had 24% lower risk of any clinical fracture compared to Japanese women. Hispanic women had significantly lower risk of any clinical, hip, and MOF fractures compared to non-Hispanic women, with no differences in fracture risk observed within Hispanic women. In this diverse sample of postmenopausal women, we confirmed racial and ethnic differences in fracture rates and risk, with novel findings among Pacific Islander women and within Asian and Hispanic subgroups.
摘要：
使用1998-2022年妇女健康倡议(WHI)数据，我们的研究提供了按种族和种族划分的当代骨折数据，特别关注西班牙裔和亚洲女性。感兴趣的骨折包括任何临床，臀部,和严重的骨质疏松性骨折（MOFs）。我们利用了2003年收集的最新种族和种族信息，其中包括七个亚洲人和五个西班牙裔人。我们计算了种族和种族类别以及亚洲和西班牙裔起源的每10000名妇女年的粗略和年龄标准化骨折发生率。我们使用Cox比例风险模型，调整年龄和WHI临床试验臂，与白人女性相比，按种族评估骨折的风险(1)，（2）亚洲血统与白人女性相比，（3）西班牙裔与非西班牙裔女性相比，和（4）亚洲和西班牙裔起源比较最普遍的起源群体。在19.4（9.2-24.2）年的中位数（四分位数范围）随访中，在160824名女性中，有44.2％的女性经历了任何临床骨折，包括36278个MOFs和8962个髋部骨折。与白人女性相比，黑色,太平洋岛民,亚洲人,多种族女性的任何临床和MOFs的风险显着降低，而只有黑人和亚洲女性的髋部骨折风险明显降低。在亚洲女性中，与日本女性相比，菲律宾女性发生任何临床骨折的风险降低了24％。西班牙裔女性的任何临床风险都显着降低，臀部,和MOF骨折与非西班牙裔女性相比，在西班牙裔起源组中观察到的骨折风险没有差异。在这个不同的绝经后妇女样本中，我们证实了骨折率和风险的种族和民族差异，在亚洲和西班牙裔亚组中的新发现。这些数据可以帮助未来的纵向研究评估骨折中种族和民族差异的贡献者。
我们提供了按种族和民族划分的当代骨折率，特别关注多个西班牙裔和亚洲亚群，使用1998-2022年妇女健康倡议的数据。在19.4年的中位随访中，154948名妇女中有43.4％经历了任何临床骨折，包括8679例髋部和34546例严重骨质疏松性骨折。与白人女性相比，黑色,太平洋岛民,亚洲人,多种族女性发生任何临床和严重骨质疏松性骨折(MOFs)的风险显著较低;而与白人女性相比,只有黑人和亚洲女性的髋部骨折风险显著较低.在亚洲女性中，与日本女性相比，菲律宾女性发生任何临床骨折的风险降低了24％。西班牙裔女性的任何临床风险都显着降低，臀部,和MOF骨折与非西班牙裔女性相比，在西班牙裔女性中观察到的骨折风险没有差异。在这个不同的绝经后妇女样本中，我们证实了骨折率和风险的种族和民族差异，在太平洋岛民妇女以及亚洲和西班牙裔亚组中的新发现。
我们提供了按种族和民族划分的当代骨折率，特别关注多个西班牙裔和亚洲亚群，使用1998-2022年妇女健康倡议的数据。在19.4年的中位随访中，154948名妇女中有43.4％经历了任何临床骨折，包括8679例髋部和34546例严重骨质疏松性骨折。与白人女性相比，黑色,太平洋岛民,亚洲人,多种族女性发生任何临床和严重骨质疏松性骨折(MOFs)的风险显著较低;而与白人女性相比,只有黑人和亚洲女性的髋部骨折风险显著较低.在亚洲女性中，与日本女性相比，菲律宾女性发生任何临床骨折的风险降低了24％。西班牙裔女性的任何临床风险都显着降低，臀部,和MOF骨折与非西班牙裔女性相比，在西班牙裔女性中观察到的骨折风险没有差异。在这个不同的绝经后妇女样本中，我们证实了骨折率和风险的种族和民族差异，在太平洋岛民妇女以及亚洲和西班牙裔亚组中的新发现。
