Abstract：
BACKGROUND: The term \"Overlap Syndrome\" (OS) describes the presence of both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in a single individual. Excessive daytime sleepiness (EDS) is a common symptom of OS shown to be associated with an increased risk of cardiovascular disease (CVD) that could be reduced through exercise. Thus, we propose to investigate a novel exercise intervention in individuals with the EDS-OS phenotype as they are at highest risk of CVD yet have the greatest barriers to exercise.
METHODS: We will conduct a single-site, randomized, two-arm, parallel group-controlled exercise trial in individuals with EDS-OS. The Epworth Sleepiness Scale (ESS) will be assessed at baseline. Individuals with OS and the EDS-OS phenotype (ESS >10) (n = 46) will be randomized to a moderate intensity interval training (MIIT, i.e. intervals of 5 min at 50% VO2peak followed by 3 min of active recovery at 10% VO2peak) or a control group of standard of care. We will investigate if MIIT intervention decreases the risk of CVD in EDS-OS, which will be assessed by: 1) quality of life, measured by the 36-Item Short Form Health Survey; 2) physical activity, measured by daily step counts; and 3) cardiovascular health, assessed as VO2peak, flow-mediated dilation and serum high sensitivity C-reactive protein, lipids, and glucose.
CONCLUSIONS: Our findings will guide future development and implementation of exercise interventions that could reduce the risk of CVD in the understudied EDS-OS phenotype.
METHODS: We will conduct a single-site, randomized, two-arm, parallel group-controlled exercise trial in individuals with EDS-OS. The Epworth Sleepiness Scale (ESS) will be assessed at baseline. Individuals with OS and the EDS-OS phenotype (ESS >10) (n = 46) will be randomized to a moderate intensity interval training (MIIT, i.e. intervals of 5 min at 50% VO2peak followed by 3 min of active recovery at 10% VO2peak) or a control group of standard of care. We will investigate if MIIT intervention decreases the risk of CVD in EDS-OS, which will be assessed by: 1) quality of life, measured by the 36-Item Short Form Health Survey; 2) physical activity, measured by daily step counts; and 3) cardiovascular health, assessed as VO2peak, flow-mediated dilation and serum high sensitivity C-reactive protein, lipids, and glucose.
CONCLUSIONS: Our findings will guide future development and implementation of exercise interventions that could reduce the risk of CVD in the understudied EDS-OS phenotype.
摘要：
背景：术语“重叠综合征”（OS）描述了在单个个体中同时存在慢性阻塞性肺疾病（COPD）和阻塞性睡眠呼吸暂停（OSA）。白天过度嗜睡（EDS）是OS的常见症状，显示与心血管疾病（CVD）的风险增加有关，可以通过运动减少。因此，我们建议对具有EDS-OS表型的个体进行新的运动干预,因为他们患CVD的风险最高,但运动障碍最大.
方法：我们将进行单站点，随机化，双臂，EDS-OS患者的平行组对照运动试验。Epworth嗜睡量表（ESS）将在基线进行评估。具有OS和EDS-OS表型（ESS>10）（n=46）的个体将被随机分配到中等强度的间歇训练（MIIT，即在50％VO2峰5分钟的间隔，然后在10％VO2峰3分钟的主动恢复）或对照组的标准护理。我们将调查MIIT干预是否降低EDS-OS中CVD的风险，这将通过以下方式进行评估：1)生活质量，由36项简短形式健康调查测量；2)身体活动，通过每日步数测量；和3)心血管健康，评估为VO2peak，血流介导的扩张和血清高敏C反应蛋白,脂质，和葡萄糖。
结论：我们的研究结果将指导未来开发和实施运动干预措施，以降低未研究的EDS-OS表型的CVD风险。
方法：我们将进行单站点，随机化，双臂，EDS-OS患者的平行组对照运动试验。Epworth嗜睡量表（ESS）将在基线进行评估。具有OS和EDS-OS表型（ESS>10）（n=46）的个体将被随机分配到中等强度的间歇训练（MIIT，即在50％VO2峰5分钟的间隔，然后在10％VO2峰3分钟的主动恢复）或对照组的标准护理。我们将调查MIIT干预是否降低EDS-OS中CVD的风险，这将通过以下方式进行评估：1)生活质量，由36项简短形式健康调查测量；2)身体活动，通过每日步数测量；和3)心血管健康，评估为VO2peak，血流介导的扩张和血清高敏C反应蛋白,脂质，和葡萄糖。
结论：我们的研究结果将指导未来开发和实施运动干预措施，以降低未研究的EDS-OS表型的CVD风险。
