METHODS: We will conduct a single-site, randomized, two-arm, parallel group-controlled exercise trial in individuals with EDS-OS. The Epworth Sleepiness Scale (ESS) will be assessed at baseline. Individuals with OS and the EDS-OS phenotype (ESS >10) (n = 46) will be randomized to a moderate intensity interval training (MIIT, i.e. intervals of 5 min at 50% VO2peak followed by 3 min of active recovery at 10% VO2peak) or a control group of standard of care. We will investigate if MIIT intervention decreases the risk of CVD in EDS-OS, which will be assessed by: 1) quality of life, measured by the 36-Item Short Form Health Survey; 2) physical activity, measured by daily step counts; and 3) cardiovascular health, assessed as VO2peak, flow-mediated dilation and serum high sensitivity C-reactive protein, lipids, and glucose.
CONCLUSIONS: Our findings will guide future development and implementation of exercise interventions that could reduce the risk of CVD in the understudied EDS-OS phenotype.
方法:我们将进行单站点,随机化,双臂,EDS-OS患者的平行组对照运动试验。Epworth嗜睡量表(ESS)将在基线进行评估。具有OS和EDS-OS表型(ESS>10)(n=46)的个体将被随机分配到中等强度的间歇训练(MIIT,即在50%VO2峰5分钟的间隔,然后在10%VO2峰3分钟的主动恢复)或对照组的标准护理。我们将调查MIIT干预是否降低EDS-OS中CVD的风险,这将通过以下方式进行评估:1)生活质量,由36项简短形式健康调查测量;2)身体活动,通过每日步数测量;和3)心血管健康,评估为VO2peak,血流介导的扩张和血清高敏C反应蛋白,脂质,和葡萄糖。
结论:我们的研究结果将指导未来开发和实施运动干预措施,以降低未研究的EDS-OS表型的CVD风险。