Abstract：
BACKGROUND: Post-meningitis deafness (PMD) is a potentially devastating cause of hearing loss among pediatric and adult patients, for which hearing rehabilitation with cochlear implants (CIs) remains the standard of care. To date, there have been limited systematic studies on the impact of cochlear ossification (CO) and time-to-implantation (TTI) on audiological outcomes.
METHODS: An online database search was performed on the PubMed, Embase, and Scopus databases for articles within the past 20 years pertaining to audiological outcomes among pediatric and adult patients with PMD. Information on study characteristics, patient demographics, clinical outcomes, and postoperative complications was collected and analyzed.
RESULTS: From 8,325 articles generated in the original search, 11 were included in the final analysis, representing 376 patients in total. Of the articles discussing TTI, the majority (3 of 4) found that a shorter TTI of 6 months on average led to improved audiological outcomes compared with control groups with a longer TTI. Of the articles that discussed the impact of preoperative CO, the majority (4 of 6) found that the presence of CO had a detrimental effect on postoperative audiological outcomes after CI. Finally, of the articles that discussed long-term audiological outcomes for PMD compared with the non-PMD control group after CI, the majority (4 of 7) found that PMD patients had inferior long-term outcomes.
CONCLUSIONS: CI is a safe and effective treatment modality for PMD, with the majority of literature demonstrating improved long-term outcomes for patients without CO and a reduced TTI.
METHODS: An online database search was performed on the PubMed, Embase, and Scopus databases for articles within the past 20 years pertaining to audiological outcomes among pediatric and adult patients with PMD. Information on study characteristics, patient demographics, clinical outcomes, and postoperative complications was collected and analyzed.
RESULTS: From 8,325 articles generated in the original search, 11 were included in the final analysis, representing 376 patients in total. Of the articles discussing TTI, the majority (3 of 4) found that a shorter TTI of 6 months on average led to improved audiological outcomes compared with control groups with a longer TTI. Of the articles that discussed the impact of preoperative CO, the majority (4 of 6) found that the presence of CO had a detrimental effect on postoperative audiological outcomes after CI. Finally, of the articles that discussed long-term audiological outcomes for PMD compared with the non-PMD control group after CI, the majority (4 of 7) found that PMD patients had inferior long-term outcomes.
CONCLUSIONS: CI is a safe and effective treatment modality for PMD, with the majority of literature demonstrating improved long-term outcomes for patients without CO and a reduced TTI.
摘要：
背景：脑膜炎后耳聋（PMD）是儿童和成人患者听力损失的潜在破坏性原因，其中，人工耳蜗（CI）的听力康复仍然是护理的标准。迄今为止,关于耳蜗骨化(CO)和植入时间(TTI)对听力学结果的影响的系统研究有限.
方法：在PubMed上进行了在线数据库搜索，Embase,和Scopus数据库中的文章在过去20年中有关儿童和成人PMD患者的听力学结果。有关研究特征的信息，患者人口统计学，临床结果，收集并分析术后并发症。
结果：来自原始搜索中生成的8,325篇文章，最终分析中包括11个，代表376名患者。在讨论TTI的文章中，大多数(4个中的3个)发现,与TTI较长的对照组相比,平均6个月的TTI较短导致听力学结果改善.在讨论术前CO影响的文章中，大多数(6个中的4个)发现CO的存在对CI后的术后听力学结果有不利影响.最后,在讨论CI后PMD与非PMD对照组的长期听力学结局的文章中,大多数(7例中的4例)发现PMD患者的长期结局较差.
结论：CI是一种安全有效的PMD治疗方法，大多数文献表明，无CO和TTI减少的患者的长期结局有所改善。
方法：在PubMed上进行了在线数据库搜索，Embase,和Scopus数据库中的文章在过去20年中有关儿童和成人PMD患者的听力学结果。有关研究特征的信息，患者人口统计学，临床结果，收集并分析术后并发症。
结果：来自原始搜索中生成的8,325篇文章，最终分析中包括11个，代表376名患者。在讨论TTI的文章中，大多数(4个中的3个)发现,与TTI较长的对照组相比,平均6个月的TTI较短导致听力学结果改善.在讨论术前CO影响的文章中，大多数(6个中的4个)发现CO的存在对CI后的术后听力学结果有不利影响.最后,在讨论CI后PMD与非PMD对照组的长期听力学结局的文章中,大多数(7例中的4例)发现PMD患者的长期结局较差.
结论：CI是一种安全有效的PMD治疗方法，大多数文献表明，无CO和TTI减少的患者的长期结局有所改善。
