PDF(Pubmed)
Abstract：
Over the past several years, messenger RNA (mRNA) vaccine has evolved from a term familiar only to vaccine scientists into one easily recognized by much of the general population. This change occurred because of the remarkable success of effective and safe mRNA vaccines during the COVID-19 pandemic that saved countless lives. Although mRNA vaccine technology has a clear use for combating future emerging diseases, its role in fighting currently known pathogens, such as HIV-1, is not well defined. This review summarizes mRNA vaccine technology, highlighting its success during the COVID-19 pandemic. It then addresses past and current efforts to develop a vaccine for HIV-1, including how mRNA vaccine technology has created opportunities in the ongoing search for an effective HIV-1 vaccine.
摘要：
在过去的几年里，信使RNA（mRNA）疫苗已经从一个只有疫苗科学家熟悉的术语发展成为一个容易被大多数普通人群识别的术语。这种变化的发生是因为在COVID-19大流行期间，有效和安全的mRNA疫苗取得了显著的成功，挽救了无数人的生命。尽管mRNA疫苗技术在对抗未来新出现的疾病方面有明确的用途，它在对抗目前已知的病原体中的作用，例如HIV-1，没有很好的定义。本文综述了mRNA疫苗技术,突出了它在COVID-19大流行期间的成功。然后讨论了过去和现在开发HIV-1疫苗的努力，包括mRNA疫苗技术如何为正在进行的寻找有效的HIV-1疫苗创造了机会。
