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Abstract：
Morphological novelties, or key innovations, are instrumental to the diversification of the organisms. In plants, one such innovation is the evolution of zygomorphic flowers, which is thought to promote outcrossing and increase flower morphological diversity. We isolated three allelic mutants from two Mimulus species displaying altered floral symmetry and identified the causal gene as the ortholog of Arabidopsis BLADE-ON-PETIOLE. We found that MlBOP and MlCYC2A physically interact and this BOP-CYC interaction module is highly conserved across the angiosperms. Furthermore, MlBOP self-ubiquitinates and suppresses MlCYC2A self-activation. MlCYC2A, in turn, impedes MlBOP ubiquitination. Thus, this molecular tug-of-war between MlBOP and MlCYC2A fine-tunes the expression of MlCYC2A, contributing to the formation of bilateral symmetry in flowers, a key trait in angiosperm evolution.
摘要：
形态新奇,或关键创新，有助于生物体的多样化。在植物中,这样的创新之一是合子花的进化，这被认为是促进异花和增加花卉形态多样性。我们从两个Mimulus物种中分离出三个等位基因突变体，这些突变体显示出改变的花对称性，并将因果基因鉴定为拟南芥BLADE-ON-PETIOLE的直系同源物。我们发现MlBOP和MlCYC2A物理相互作用，并且该BOP-CYC相互作用模块在被子植物中高度保守。此外，MlBOP自泛素化并抑制MlCYC2A自激活。MlCYC2A,反过来,阻碍MlBOP泛素化。因此，MlBOP和MlCYC2A之间的这种分子拉锯战微调了MlCYC2A的表达，有助于花的双侧对称性的形成，被子植物进化的一个关键特征.
