PDF(Pubmed)
Abstract：
Photoelectrochemical (PEC) nanobiosensors integrate molecular (bio)recognition elements with semiconductor/plasmonic photoactive nanomaterials to produce measurable signals after light-induced reactions. Recent advancements in PEC nanobiosensors, using light-matter interactions, have significantly improved sensitivity, specificity, and signal-to-noise ratio in detecting (bio)analytes. Tunable nanomaterials activated by a wide spectral radiation window coupled to electrochemical transduction platforms have further improved detection by stabilizing and amplifying electrical signals. This work reviews PEC biosensors based on nanomaterials like metal oxides, carbon nitrides, quantum dots, and transition metal chalcogenides (TMCs), showing their superior optoelectronic properties and analytical performance for the detection of clinically relevant biomarkers. Furthermore, it highlights the innovative role of red light and NIR-activated PEC nanobiosensors in enhancing charge transfer processes, protecting them from biomolecule photodamage in vitro and in vivo applications. Overall, advances in PEC detection systems have the potential to revolutionize rapid and accurate measurements in clinical diagnostic applications. Their integration into miniaturized devices also supports the development of portable, easy-to-use diagnostic tools, facilitating point-of-care (POC) testing solutions and real-time monitoring.
摘要：
光电化学（PEC）纳米生物传感器将分子（生物）识别元件与半导体/等离子体光敏纳米材料集成在一起，以在光诱导反应后产生可测量的信号。PEC纳米生物传感器的最新进展，利用光-物质相互作用，灵敏度显著提高，特异性，和检测（生物）分析物的信噪比。由耦合到电化学转导平台的宽光谱辐射窗口激活的可调谐纳米材料通过稳定和放大电信号进一步改善了检测。这项工作回顾了基于金属氧化物等纳米材料的PEC生物传感器，碳氮化物，量子点,和过渡金属硫族化物(TMC)，显示其优异的光电特性和分析性能，用于检测临床相关的生物标志物。此外，它强调了红光和近红外激活的PEC纳米生物传感器在增强电荷转移过程中的创新作用，保护它们免受体外和体内应用的生物分子光损伤。总的来说,PEC检测系统的进步有可能彻底改变临床诊断应用中快速准确的测量。它们集成到小型化设备中也支持便携式设备的发展，易于使用的诊断工具，促进即时(POC)测试解决方案和实时监控。
